Emmanuel Esquivel

Data from Convergent Genetic Adaptation in Human Tumors Developed Under Systemic Hypoxia and in Populations Living at High Altitudes

Carlota Arenillas, Lucía Celada, José Ruiz-Cantador, Bruna Calsina et autres

Abstract This study explores parallels between systemic hypoxia adaptation in high-altitude populations and tumorigenesis. We identified EPAS1, a gene critical for hypoxia adaptation in populations such as Tibetans and Sherpas, as playing a similar adaptive role in tumors arising under hypoxic conditions. …

Supplementary Tables S1-S16 from Convergent Genetic Adaptation in Human Tumors Developed Under Systemic Hypoxia and in Populations Living at High Altitudes

Carlota Arenillas, Lucía Celada, José Ruiz-Cantador, Bruna Calsina et autres

Supplementary Tables Supplementary Table S1. Clinical and Tumoral Data from CCHD-PPGL patients. Supplementary Table S2. Selection inference in the PPGL (TCGA, non-CCHD) and CCHD-PPGL cohort. Supplementary Table S3. Cancer Cell Fraction of EPAS1 mutations in CCHD-PPGL and PPGL patients. Supplementary Table S4. …

Supplementary Figures S1-S23 from Convergent Genetic Adaptation in Human Tumors Developed Under Systemic Hypoxia and in Populations Living at High Altitudes

Carlota Arenillas, Lucía Celada, José Ruiz-Cantador, Bruna Calsina et autres

Supplementary Figure S1. Description of the CCHD-PPGL cohort of 27 individuals with CCHD who developed 38 PPGL tumors. Supplementary Figure S2. Summary of the clinical features of patients with CCHD-PPGL. Supplementary Figure S3. EPAS1 mutations are enriched in the hypoxic cohort of …

Supplementary Tables S1-S16 from Convergent Genetic Adaptation in Human Tumors Developed Under Systemic Hypoxia and in Populations Living at High Altitudes

Carlota Arenillas, Lucía Celada, José Ruiz-Cantador, Bruna Calsina et autres

Supplementary Tables Supplementary Table S1. Clinical and Tumoral Data from CCHD-PPGL patients. Supplementary Table S2. Selection inference in the PPGL (TCGA, non-CCHD) and CCHD-PPGL cohort. Supplementary Table S3. Cancer Cell Fraction of EPAS1 mutations in CCHD-PPGL and PPGL patients. Supplementary Table S4. …

Supplementary Figures S1-S23 from Convergent Genetic Adaptation in Human Tumors Developed Under Systemic Hypoxia and in Populations Living at High Altitudes

Carlota Arenillas, Lucía Celada, José Ruiz-Cantador, Bruna Calsina et autres

Supplementary Figure S1. Description of the CCHD-PPGL cohort of 27 individuals with CCHD who developed 38 PPGL tumors. Supplementary Figure S2. Summary of the clinical features of patients with CCHD-PPGL. Supplementary Figure S3. EPAS1 mutations are enriched in the hypoxic cohort of …

Convergent Genetic Adaptation in Human Tumors Developed Under Systemic Hypoxia and in Populations Living at High Altitudes

Carlota Arenillas, Lucía Celada, José Ruiz-Cantador, Bruna Calsina et autres

Abstract This study explores parallels between systemic hypoxia adaptation in high-altitude populations and tumorigenesis. We identified EPAS1, a gene critical for hypoxia adaptation in populations such as Tibetans and Sherpas, as playing a similar adaptive role in tumors arising under hypoxic conditions. …

es, nl, us, de, au, br, fr, se, at (code pays fourni par la source)

Playbook workflow builder: Interactive construction of bioinformatics workflows

Daniel Clarke, John Erol Evangelista, Zhuorui Xie, Giacomo B. Marino et autres

The Playbook Workflow Builder (PWB) is a web-based platform to dynamically construct and execute bioinformatics workflows by utilizing a growing network of input datasets, semantically annotated API endpoints, and data visualization tools contributed by an ecosystem of collaborators. Via a user-friendly user …

us (code pays fourni par la source)

Convergent genetic adaptation in human tumors developed under systemic hypoxia and in populations living at high altitudes

Carlota Arenillas, José Ruiz-Cantador, Lucía Celada, Bruna Calsina et autres

Abstract EPAS1 HIF2α is the primary gene implicated in systemic hypoxia adaptation. Conversely, aberrantly activated EPAS1 HIF2α acts as a tumor driver against which anti-tumor therapeutics are proven effective. We elucidated connections between adaptation to systemic hypoxia in high-altitude populations, such as …

es, nl, us, au, br, fr, se, at (code pays fourni par la source)

Playbook Workflow Builder: Interactive Construction of Bioinformatics Workflows from a Network of Microservices

Daniel Clarke, John Erol Evangelista, Zhuorui Xie, Giacomo B. Marino et autres

Abstract Many biomedical research projects produce large-scale datasets that may serve as resources for the research community for hypothesis generation, facilitating diverse use cases. Towards the goal of developing infrastructure to support the findability, accessibility, interoperability, and reusability (FAIR) of biomedical digital …

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exRNA-eCLIP intersection analysis reveals a map of extracellular RNA binding proteins and associated RNAs across major human biofluids and carriers

Emily L. LaPlante, Alessandra Stürchler, Robert Fullem, David Chen et autres

Although the role of RNA binding proteins (RBPs) in extracellular RNA (exRNA) biology is well established, their exRNA cargo and distribution across biofluids are largely unknown. To address this gap, we extend the exRNA Atlas resource by mapping exRNAs carried by extracellular …

us, ch (code pays fourni par la source)

exRNA-eCLIP intersection analysis reveals a map of extracellular RNA binding proteins and associated RNAs across major human biofluids and carriers

Emily L. LaPlante, Alessandra Stürchler, Robert Fullem, David Chen et autres

us, ch, il (code pays fourni par la source)

exRNA-eCLIP intersection analysis reveals a map of extracellular RNA binding proteins and associated RNAs across major human biofluids and carriers.

Emily L. LaPlante, Alessandra Stürchler, Robert Fullem, David Chen et autres

Code relating to the analysis of exRBPs and their exRNA cargo in human biofluids.

us, ch, il (code pays fourni par la source)