Accès ouvert
2026
preprint
OpenAlex
Maike Weber, Andrea Witowski, Malte Bayer, Frederick Krause et autres
Background Sepsis is the primary driver of mortality in intensive care. Personalized medicine requires an accurate understanding of the syndrome, and plasma proteomics is increasingly used to characterize its molecular alterations. Comorbidities, demographics and postoperative sterile inflammation complicate this task, and proteins …
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Accès ouvert
2025
article
OpenAlex
Christoph Sombetzki, Lars Palmowski, Dominik Ziehe, Hartmuth Nowak et autres
The glucocorticoid receptor (GR), particularly its isoforms GRα and GRβ, plays a crucial role in modulating inflammatory responses. The rs6198 single nucleotide polymorphism (SNP) in the NR3C1 gene, which encodes GR, has been associated with adverse outcomes in various diseases due to …
de
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Accès ouvert
2024
article
OpenAlex
Andrea Witowski, Lars Palmowski, Tim Rahmel, Hartmuth Nowak et autres
PURPOSE: There is evidence that lower activity of the RAF/MEK/ERK network is associated with positive outcomes in mild and moderate courses of COVID-19. The effect of this cascade in COVID-19 sepsis is still undetermined. Therefore, we tested the hypothesis that activity of …
de
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Accès ouvert
2024
article
OpenAlex
Patrick Thon, Ellen Trübner, Frieda Zimmer, Lars Palmowski et autres
Background Metabolic derangements in sepsis stem from mitochondrial injury and contribute to organ dysfunction and mortality. Thus, repair of mitochondrial damage seems pivotal for recovery and determining clinical outcome in sepsis. However, reliable biomarkers assessing mitochondrial repair noninvasively in peripheral blood are …
de
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Accès ouvert
2022
article
OpenAlex
Matthias Unterberg, Tim Rahmel, Katharina Rump, Alexander Wolf et autres
BACKGROUND: The COVID-19 pandemic has taken a toll on health care systems worldwide, which has led to increased mortality of different diseases like myocardial infarction. This is most likely due to three factors. First, an increased workload per nurse ratio, a factor …
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