Vicki Rosen

Abstract 4368485: BMP3 Overexpression Attenuates Pulmonary Arterial Hypertension

Aymen Halouani, Eric Mensah, Zaujia Athumani, Michael G. Katz et autres

Backgound: Pulmonary arterial hypertension (PAH), a rare and progressive subtype of pulmonary hypertension (PH), leads to right heart failure and, ultimately, death. PH is defined by a mean pulmonary arterial pressure greater than 20 mmHg at rest, assessed via right heart catheterization. …

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Adipocyte cell therapy targeting BMP signaling alleviates fibroadipose tissue deposition in secondary lymphedema

Ziyu Chen, Mengfan Wu, Samerender Nagam Hanumantharao, Pratik Koirala et autres

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CXXC Finger Protein 1 drives BMP signaling and progenitor cell differentiation during limb development

Emanuele Pignatti, Lijie Jiang, Manasvi S. Shah, Anish Karpurapu et autres

The mechanisms mediating endochondral bone formation remain incompletely understood. Here, we show that CXXC Finger Protein 1 (CFP1) is required for the onset of chondrogenesis during forelimb development. CFP1-deficient mesenchymal progenitor cells (LMPs) retain an immature molecular signature with elevated FGF and …

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Acute regulation of murine adipose tissue lipolysis and insulin resistance by the TGFβ superfamily protein GDF3

Nagasuryaprasad Kotikalapudi, Deepti Ramachandran, Daniel Vieira, William B. Rubio et autres

TGFβ superfamily proteins can affect cellular differentiation, thermogenesis, and fibrosis in mammalian adipose tissue. Here we describe a role for Growth Differentiation Factor 3 (GDF3) on mature adipocyte biology. We find inducible GDF3 loss of function in obese adult mice leads to …

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Complex Regulatory Interactions at GDF5 Shape Joint Morphology and Osteoarthritis Disease Risk

Clarissa Coveney, David E. Maridas, Hao Chen, Pushpanathan Muthuirulan et autres

OBJECTIVE: The objective of this study was to reveal causal-level osteoarthritis (OA) disease biology by targeting regulatory interactions at GDF5. METHODS: By investigating different GDF5 regulatory regions (R2, R3-R5, R7-R9, R18-R20, GROW1), we explored their functional impacts on gene expression and joint …

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6443 The Role of GDF5 in Regulating Enthesopathy Development in the Hyp mouse Model of XLH

Ashleigh Hughes, Melissa Sorsby, Shaza Almardini, Shreya Venkat et autres

Abstract Disclosure: A. Hughes: None. M. Sorsby: None. S. Almardini: None. S. Venkat: None. A. Alayyat: None. M. Rahman: None. J. Baker: None. R. Rana: None. V. Rosen: None. E.S. Liu: Advisory Board Member; Self; Ascendis Pharma. Other; Self; Inozyme - DSMB. …

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A novel methodology utilizing microchip implants to monitor individual activity and body temperature for assessing knee pain in group-housed rats

Shoichi Hasegawa, R. Yamashita, Yusuke Nakagawa, Kazumasa Miyatake et autres

The pain assessment in animals is challenging as they cannot verbally express the site and severity of pain. In this study, we tried a small implantable actimeter, "Nanotag", to monitor spontaneous locomotor activity and body temperature in animals suffering from a chemical-induced …

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The role of GDF5 in regulating enthesopathy development in the Hyp mouse model of XLH

Melissa Sorsby, Shaza Almardini, Ahmad Alayyat, Ashleigh Hughes et autres

X-linked hypophosphatemia (XLH) is caused by mutations in PHEX, leading to rickets and osteomalacia. Adults affected with XLH develop a mineralization of the bone-tendon attachment site (enthesis), called enthesopathy, which causes significant pain and impaired movement. Entheses in mice with XLH (Hyp) …

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04. Development Of A Bone Marrow-resident Cell Therapy For Tissue Repair During Genetic Heterotopic Ossification

Pratik Koirala, Ziyu Chen, Mengfan Wu, Samerender Nagam Hunamantharao et autres

Purpose: Fibrodysplasia Ossificans Progressiva (FOP) is a rare genetic disorder characterized by a R206H mutation in the ACVR1 receptor which causes progressive heterotopic ossification (HO) where muscle, tendons, and ligaments are slowly replaced by bones causing loss of mobility, difficulty in speaking, …

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Effects of dexamethasone and IGF-1 on post-traumatic osteoarthritis-like catabolic changes in a human cartilage-bone-synovium microphysiological system in space and ground control tissues on earth

Garima Dwivedi, Lisa L. Flaman, Begum Alaybeyoglu, Eliot H. Frank et autres

Post-traumatic Osteoarthritis (PTOA) results from traumatic joint injuries (such as an ACL rupture). Mechanical impact and an immediate synovial inflammatory response can result in joint tissue degradation and longer-term progression to PTOA. Astronauts are susceptible to increased exercise-related joint injuries leading to …

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PPARγ agonist treatment reduces fibroadipose tissue in secondary lymphedema by exhausting fibroadipogenic PDGFRα+ mesenchymal cells

Ziyu Chen, Soheila Ali Akbari Ghavimi, Mengfan Wu, John McNamara et autres

Secondary lymphedema occurs in up to 20% of patients after lymphadenectomy performed for the surgical management of tumors involving the breast, prostate, uterus, and skin. Patients develop progressive edema of the affected extremity due to retention of protein-rich lymphatic fluid. Despite compression …

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A periosteum-derived cell line to study the role of BMP/TGFβ signaling in periosteal cell behavior and function

Emily R. Moore, David E. Maridas, Laura W. Gamer, Gavin Chen et autres

The periosteum is a thin tissue surrounding each skeletal element that contains stem and progenitor cells involved in bone development, postnatal appositional bone growth, load-induced bone formation, and fracture repair. BMP and TGFβ signaling are important for periosteal activity and periosteal cell …

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