Lingling Yu

Glycan shielding enables TCR-sufficient allogeneic CAR-T therapy

Zeguang Wu, Jinhong Shi, Qiezhong Lamao, Yuanyuan Qiu et autres

Despite the success of autologous chimeric antigen receptor (CAR)-T cell therapy, achieving persistence and avoiding rejection in allogeneic settings remains challenging. We showed that signal peptide peptidase-like 3 (SPPL3) deletion enabled glycan-mediated immune evasion in primary T cells. SPPL3 deletion modified glycan …

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Rutin targets AKT to inhibit ferroptosis in ventilator‐induced lung injury

Shengsong Chen, Zhonghao Li, Yuhong Xiao, Zhaobin Zhou et autres

Our previous research confirmed that rutin reduced ventilator-induced lung injury (VILI) in mice. Ferroptosis has been reported to participate in the pathogenic process of VILI. We will explore whether rutin inhibits ferroptosis to alleviate VILI. A mouse model of VILI was constructed …

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Highly multiplexed quantifications of 299 somatic mutations in colorectal cancer patients by automated MALDI-TOF mass spectrometry

Chang Xu, Danli Peng, Jialu Li, Meihua Chen et autres

BACKGROUND: Detection of somatic mutations in tumor tissues helps to understand tumor biology and guide treatment selection. Methods such as quantitative PCR can analyze a few mutations with high efficiency, while next generation sequencing (NGS) based methods can analyze hundreds to thousands …

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Highly multiplexed quantifications of 299 somatic mutations in colorectal cancer patients by automated MALDI-TOF mass spectrometry

Chang Xu, Danli Peng, Jialu Li, Meihua Chen et autres

cn (code pays fourni par la source)

Highly multiplexed quantifications of 299 somatic mutations in colorectal cancer patients by automated MALDI-TOF mass spectrometry

Chang Xu, Danli Peng, Jialu Li, Meihua Chen et autres

cn (code pays fourni par la source)

Highly multiplexed quantifications of 299 somatic mutations in colorectal cancer patients by automated MALDI-TOF mass spectrometry

Chang Xu, Danli Peng, Jialu Li, Meihua Chen et autres

cn (code pays fourni par la source)

Additional file 1 of Highly multiplexed quantifications of 299 somatic mutations in colorectal cancer patients by automated MALDI-TOF mass spectrometry

Chang Xu, Danli Peng, Jialu Li, Meihua Chen et autres

Additional file 1 Table S1. Mutation list of CRC panel. Table S2. Primer sequences for mutation detection by CRC panel. Table S3. Primer sequences for mutation validation by Sanger sequencing. (XLS 145 kb)

cn (code pays fourni par la source)

Highly multiplexed quantifications of 299 somatic mutations in colorectal cancer patients by automated MALDI-TOF mass spectrometry

Chang Xu, Danli Peng, Jialu Li, Meihua Chen et autres

cn (code pays fourni par la source)