Accès ouvert
2026
erratum
OpenAlex
Sarkis Sarkis, Anna Gutowska, Mohammad Arif Rahman, Luca Schifanella et autres
In the version of this article initially published, there were data-entry errors in the Source Data for Fig. 3 and Supplementary Figs. 6, 7 for week 21 bronchoalveolar lavage (BAL) neutrophil-frequency values for animal DHF6. Following correction of the Source Data and …
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Accès ouvert
2026
article
OpenAlex
Isabela Silva de Castro, Mohammad Arif Rahman, Massimiliano Bissa, Katherine C. Goldfarbmuren et autres
We evaluate the efficacy and immunogenicity of HIV clade A/E A244 envelope (Env) immunogens with the 23 amino acids of variable region 1 deleted (ΔV1) or retained (wild-type [WT]) in macaques. Only the ΔV1 regimen significantly reduces the risk of mucosal acquisition …
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Accès ouvert
2026
article
OpenAlex
Emmanuel K. Woode, Katherine C. Goldfarbmuren, Oluwatobi T. Arisa, Massimiliano Bissa et autres
Background Topical administration of SAMT-247, a mercaptobenzamide thioester zinc finger inhibitor targeting the HIV nucleocapsid Gag zinc finger protein, generates multiple metabolites in mucosal tissues, including Met-A, Met-B, Met-C, and Met-D. Prior studies established that SAMT-247, delivered either as a vaginal gel …
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2026
article
OpenAlex
Massimiliano Bissa, Slim Fourati, Sohyoung Kim, Luca Schifanella et autres
Abstract Introduction The development of an effective anti-HIV vaccine remains a critical tool to halt the HIV epidemic, particularly due to the limits of the PrEP strategies. CD4+ T lymphocytes play a crucial role in vaccine efficacy; however, they are also the …
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Accès ouvert
2026
dataset
OpenAlex
Taha Hayal, Diana M. Abraham, Selami Demirci, Xing Fan et autres
This file contains the datasets used for the paper's figures, as well as the raw flow cytometry data.
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Accès ouvert
2026
dataset
OpenAlex
Taha Hayal, Diana M. Abraham, Selami Demirci, Xing Fan et autres
This file contains the datasets used for the paper's figures, as well as the raw flow cytometry data.
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Accès ouvert
2026
article
OpenAlex
Mohammad Arif Rahman, Emmanuel K. Woode, John A. Moss, Massimiliano Bissa et autres
We assess the combined effect of sustained mucosal delivery of the anti-HIV small molecule S-acyl-2-mercaptobenzamide thioester 247 (SAMT-247) via an intravaginal ring (IVR) and ΔV1DNA/ALVAC-SIV/ΔV1gp120/alum (ΔV1-SIV) immunization in female macaques. The combined approach reduces the risk of vaginal SIV mac251 infection by …
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Accès ouvert
2026
preprint
OpenAlex
Connor P. Jewell, Andrew J. Perciaccante, Kate Brown, Tapan K. Maity et autres
Covalent modification of target proteins is a well-established mechanism of action for small molecule inhibitors. Cysteine residues in particular have been exploited for their reactivity toward electrophilic molecules. SAMT-247 is a mercaptobenzamide thioester that covalently acetylates cysteines in the zinc-coordinating domains of …
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Accès ouvert
2026
article
OpenAlex
Kasey Stokdyk, Anusmita Sahoo, Sailaja Gangadhara, LaTonya D. Williams et autres
The development of an effective HIV-1 vaccine is of paramount importance to global health. Here, we compared the influence of two adjuvants, Escherichia coli double-mutant heat-labile toxin (dmLT) and alum, on the protective immunity induced by a cyclically permuted trimeric HIV-1 envelope …
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Accès ouvert
2025
article
OpenAlex
Shikha Shrivastava, Joshua M. Carmen, Jiae Kim, Kristina K. Peachman et autres
Abstract Adjuvants play an important role in modulating antigen-specific immune responses. We conducted a comparative adjuvant immunogenicity study in Rhesus macaques using HIV-1 subtype B gp120 envelope protein, B.63521, formulated with aluminum hydroxide gel (AH), or a family of liposomal adjuvants known …
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Accès ouvert
2025
article
OpenAlex
Massimiliano Bissa, Mohammad Arif Rahman, Luca Schifanella, Katherine C. Goldfarbmuren et autres
Abstract Simian or Human immunodeficiency virus (SIV or HIV) vaccines based on V1-deleted envelope virus-like particles, delivered by the DNA/ALVAC platforms, followed by the ΔV1gp120 boost formulated in Alum, protect 50% and 80% of macaques from mucosal infection with SIV mac251 or …
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Accès ouvert
2025
article
OpenAlex
Sarkis Sarkis, Anna Gutowska, Mohammad Arif Rahman, Luca Schifanella et autres
Abstract HTLV-1 type-A rarely causes lung disease in humans, whereas HTLV-1 type-C is more frequently associated with respiratory failure and premature death. We investigated the genetic basis of HTLV-1C morbidity by constructing a chimeric HTLV-1A/C oI-L encompassing the highly divergent type C …
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