PASTA: versatile tyramide-oligonucleotide amplification for multimodal spatial biology
Hendrik A. Michel, Paige McCallum, Wenrui Wu, Huaying Qiu et autres
us, ca, it, au, sg (code pays fourni par la source)
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Nature Methods
Lindsay K. Parmelee
Informations fournies par OpenAlex. Research Africa ne déduit ni nationalité, ni poste, ni coordonnées personnelles.
32Publications signalées
73Citations signalées
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Single-cell and spatial transcriptomicsBirth, Development, and HealthCancer Immunotherapy and BiomarkersAdvanced biosensing and bioanalysis techniquesPregnancy and preeclampsia studies
Les publications récentes
Supp Table 9 from Same-Slide Spatial Multiomics Integration with IN-DEPTH Reveals Tumor Virus–Linked Spatial Reorganization of the Tumor Microenvironment
Stephanie Pei Tung Yiu, Yuzhou Chang, Yao Yu Yeo, Huaying Qiu et autres
Enrichment pathways in LMP1-positive and LMP1-negative tumors and their neighboring macrophages.
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Supp Table 10 from Same-Slide Spatial Multiomics Integration with IN-DEPTH Reveals Tumor Virus–Linked Spatial Reorganization of the Tumor Microenvironment
Stephanie Pei Tung Yiu, Yuzhou Chang, Yao Yu Yeo, Huaying Qiu et autres
Mean expression, statistical metrics, and Log2fold change of ligand-receptor interactions.
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Supp Table 11 from Same-Slide Spatial Multiomics Integration with IN-DEPTH Reveals Tumor Virus–Linked Spatial Reorganization of the Tumor Microenvironment
Stephanie Pei Tung Yiu, Yuzhou Chang, Yao Yu Yeo, Huaying Qiu et autres
Patient metadata for the DLBCL cohorts included in this study.
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Supp Table 1 from Same-Slide Spatial Multiomics Integration with IN-DEPTH Reveals Tumor Virus–Linked Spatial Reorganization of the Tumor Microenvironment
Stephanie Pei Tung Yiu, Yuzhou Chang, Yao Yu Yeo, Huaying Qiu et autres
Details of the antibody panel used in all IN-DEPTH experiments throughout the study including antibody clones, vendors, working concentrations, imaging channel, imaging cycle and exposure time.
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Data from Same-Slide Spatial Multiomics Integration with IN-DEPTH Reveals Tumor Virus–Linked Spatial Reorganization of the Tumor Microenvironment
Stephanie Pei Tung Yiu, Yuzhou Chang, Yao Yu Yeo, Huaying Qiu et autres
Abstract Spatial transcriptomics and proteomics have enabled profound insights into tissue organization, yet these technologies remain largely disparate, and emerging same-slide multiomics approaches are limited in plex, spatial resolution, signal retention, and integrative analytics. We introduce IN-situ DEtailed Phenotyping To High-resolution transcriptomics …
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Supp Table 5 from Same-Slide Spatial Multiomics Integration with IN-DEPTH Reveals Tumor Virus–Linked Spatial Reorganization of the Tumor Microenvironment
Stephanie Pei Tung Yiu, Yuzhou Chang, Yao Yu Yeo, Huaying Qiu et autres
Details of batch effect correction for the DLBCL IN-DEPTH datasets.
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Supp Fig 10 from Same-Slide Spatial Multiomics Integration with IN-DEPTH Reveals Tumor Virus–Linked Spatial Reorganization of the Tumor Microenvironment
Stephanie Pei Tung Yiu, Yuzhou Chang, Yao Yu Yeo, Huaying Qiu et autres
Additional supporting data for the ligand-receptor analysis.
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Supp Fig 5 from Same-Slide Spatial Multiomics Integration with IN-DEPTH Reveals Tumor Virus–Linked Spatial Reorganization of the Tumor Microenvironment
Stephanie Pei Tung Yiu, Yuzhou Chang, Yao Yu Yeo, Huaying Qiu et autres
Additional antibody staining specificity validation and cell phenotyping maps across DLBCL tissue sections.
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Supp Fig 6 from Same-Slide Spatial Multiomics Integration with IN-DEPTH Reveals Tumor Virus–Linked Spatial Reorganization of the Tumor Microenvironment
Stephanie Pei Tung Yiu, Yuzhou Chang, Yao Yu Yeo, Huaying Qiu et autres
Additional details on the CODEX-GeoMx spatial alignment, integration workflow, and batch effect correction for the DLBCL cohort.
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Supp Table 7 from Same-Slide Spatial Multiomics Integration with IN-DEPTH Reveals Tumor Virus–Linked Spatial Reorganization of the Tumor Microenvironment
Stephanie Pei Tung Yiu, Yuzhou Chang, Yao Yu Yeo, Huaying Qiu et autres
GSVA pathways identified in DLBCL datasets at multicellular and single-cell resolution using SGCC.
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Supp Fig 4 from Same-Slide Spatial Multiomics Integration with IN-DEPTH Reveals Tumor Virus–Linked Spatial Reorganization of the Tumor Microenvironment
Stephanie Pei Tung Yiu, Yuzhou Chang, Yao Yu Yeo, Huaying Qiu et autres
Additional validation and parameter optimization of the SGCC method, including simulation benchmarking against classical spatial statistical methods and robustness testing across parameter settings.
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