Andrea Natali

A narrative review of what cohorts have taught us and how they have laid the foundation for much of our understanding of type 2 diabetes

Sun H. Kim, Ipsa Arora, Charles O Agyemang, Ranjit Mohan Anjana et autres

This narrative review provides a historical perspective on how observational research on type 2 diabetes has been developed and consolidated over the last 50 years and how well-designed cohort studies will provide us with knowledge for research and practice in the future …

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APOC3 LINKS DIVERGENT ATHEROGENIC AND HEPATIC PHENOTYPES: CLINICAL AND UK BIOBANK GENETIC EVIDENCE

Cecilia Morgantini, Lorenzo Luciani, Simona Baldi, Martina Chiariacó et autres

Associations of the inflammasome-dependent cytokine IL-18 with risk of coronary heart disease

Harry Björkbacka, Isabel Gonçalves, Gunnar Engström, Alexandru Șchiopu et autres

AIMS: Inflammasome activation has emerged as a promising therapeutic target to reduce residual cardiovascular (CV) risk in patients on guideline lipid-lowering therapy. IL-1β and IL-6 have been intensively studied, whereas the role of the inflammasome-related cytokine IL-18 has gained less attention. Here …

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Oral glucose absorption is enhanced in early metabolic dysfunction-associated steatotic liver disease

Domenico Tricò, Tongzhi Wu, Noemi Cimbalo, Martina Chiriacò et autres

AIMS/HYPOTHESIS: Hepatic glucose flux plays a crucial role in the progression of metabolic dysfunction-associated steatotic liver disease (MASLD), promoting de novo lipogenesis, inflammation and fibrosis. This study aimed to evaluate the kinetics of oral glucose absorption and one of its key modulators, …

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Exercise Metabolic Flexibility in Type 2 Diabetes Treated With Empagliflozin: An Exploratory Analysis of the Randomised Trial EMPA ‐ HEART

Lorenzo Nesti, Lorenza Santoni, Simona Baldi, Maria Tiziana Scozzaro et autres

ABSTRACT Aim Patients with type 2 diabetes (T2D) often develop metabolic inflexibility and reduced exercise capacity. We examined whether sodium‐glucose cotransporter 2 inhibitors (SGLT2i) modify substrate oxidation during exercise. Methods As a pre‐specified exploratory analysis, aimed at understanding the relevance of circulating …

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Quantifying the individual disease duration-adjusted burden of complications in persons with type 2 diabetes

Luca Sacchetta, Simone Gallo, Martina Chiriacò, Dario Tumino et autres

BACKGROUND AND AIMS: The burden of type 2 diabetes (T2D)-related complications (DRCs) shows marked interindividual variability. We aimed to develop a method to estimate the burden and rate of accumulation of complications in relation to disease duration using standard clinical assessments. METHODS …

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Author response for "Exercise metabolic flexibility in type 2 diabetes treated with empagliflozin: an exploratory analysis of the randomized trial EMPA-HEART"

Lorenzo Nesti, Lorenza Santoni, Simona Baldi, Maria Tiziana Scozzaro et autres

Impact of overweight and obesity on fasting insulin secretion in men and women without diabetes: effect sizes and mechanisms

Martina Chiriacò, Domenico Tricò, John R. Petrie, Rafael Gabriel et autres

AIMS/HYPOTHESIS: Fasting hyperinsulinaemia is a key feature of obesity and is implicated in diabetes progression. However, the following aspects of insulin secretion remain unclear: (1) which index of obesity is most important; (2) what is the shape of the dose-response curve between …

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Impact of background insulin treatment on cardiorenal outcomes in patients with type 2 diabetes: a patient-level analysis of merged CANVAS and CREDENCE trials

Martina Chiriacò, Domenico Trico, Luca Sacchetta, Lorenzo Nesti et autres

Abstract Background/Introduction The impact of insulin on cardiorenal outcomes in type 2 diabetes (T2D) remains unclear among anti-diabetic treatments, while the proposed cardiovascular (CV) benefits of metformin are not well established. Additionally, although canagliflozin is known to lower cardiorenal risk, its specific …

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Effects of 6-month treatment with the GLP-1 receptor agonist liraglutide on 24-hour energy metabolism and body composition in adults with obesity

Alessio Basolo, Paolo Piaggi, Valentina Angeli, Susanna Bechi Genzano et autres

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Comparison of Ramp and Step Graded Cardiopulmonary Exercise Tests for the Estimate of Substrate Oxidation Rates in Recreationally Active Individuals

Lorenzo Nesti, Lorenza Santoni, Silvia Frascerra, Martina Chiriacò et autres

Fat oxidation rates are key determinants of exercise capacity and metabolic health, evaluated by indirect calorimetry during step graded exercise test. We sought to verify whether indirect calorimetry applied to ramp graded exercise test provides comparable results to the reference test and …

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CARDIOPULMONARY AND METABOLIC CHARACTERIZATION OF EFFORT INTOLERANCE IN HEART FAILURE WITH PRESERVED EJECTION FRACTION: DISSECTING THE EFFECT OF TYPE 2 DIABETES

Lorenzo Nesti, Nicola Riccardo Pugliese, L Santoni, L Sacchetta et autres

Abstract Background and aims Heart failure with preserved ejection fraction (HFpEF) is frequent and challeging clinical syndrome among patients with diabetes whose pathophysiology remains relatively poorly characterized; we aimed at analyzing the effects of diabetes on cardiopulmonary and metabolic determinants of effort …

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