Nikola P. Konstandin

Acute megakaryoblastic leukaemia shows high frequency of chromosome 1q aberrations and dismal outcome

Friederike Pastore, Hanna Gittinger, S. Raab, Sebastian Tschuri et autres

Acute megakaryoblastic leukaemia (AMKL) is associated with poor prognosis. Limited information is available on its cytogenetics, molecular genetics and clinical outcome. We performed genetic analyses, evaluated prognostic factors and the value of allogeneic haematopoietic stem cell transplantation (allo-HSCT) in a homogenous adult …

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Data from Evolution of Cytogenetically Normal Acute Myeloid Leukemia During Therapy and Relapse: An Exome Sequencing Study of 50 Patients

Philipp A. Greif, Luise Hartmann, Sebastian Vosberg, Sophie M. Stief et autres

Abstract Purpose: To study mechanisms of therapy resistance and disease progression, we analyzed the evolution of cytogenetically normal acute myeloid leukemia (CN-AML) based on somatic alterations. Experimental Design: We performed exome sequencing of matched diagnosis, remission, and relapse samples from 50 CN-AML …

Supplementary Figures from Evolution of Cytogenetically Normal Acute Myeloid Leukemia During Therapy and Relapse: An Exome Sequencing Study of 50 Patients

Philipp A. Greif, Luise Hartmann, Sebastian Vosberg, Sophie M. Stief et autres

Figure S1 Recurrently mutated genes and comparison to TCGA cohort. Figure S2 Stabililty of recurrently mutated genes over disease course. Figure S3 Variant allele frequency plots from diagnosis to relapse for each individual patient. Figure S4 Mutation patterns of individual genes. Lines …

Table S2 from Evolution of Cytogenetically Normal Acute Myeloid Leukemia During Therapy and Relapse: An Exome Sequencing Study of 50 Patients

Philipp A. Greif, Luise Hartmann, Sebastian Vosberg, Sophie M. Stief et autres

Detailed patient characteristics

Table S4 from Evolution of Cytogenetically Normal Acute Myeloid Leukemia During Therapy and Relapse: An Exome Sequencing Study of 50 Patients

Philipp A. Greif, Luise Hartmann, Sebastian Vosberg, Sophie M. Stief et autres

Mutation profile of the cell lines MM-1 and MM-6

Data from Evolution of Cytogenetically Normal Acute Myeloid Leukemia During Therapy and Relapse: An Exome Sequencing Study of 50 Patients

Philipp A. Greif, Luise Hartmann, Sebastian Vosberg, Sophie M. Stief et autres

Abstract Purpose: To study mechanisms of therapy resistance and disease progression, we analyzed the evolution of cytogenetically normal acute myeloid leukemia (CN-AML) based on somatic alterations. Experimental Design: We performed exome sequencing of matched diagnosis, remission, and relapse samples from 50 CN-AML …

Table S3 from Evolution of Cytogenetically Normal Acute Myeloid Leukemia During Therapy and Relapse: An Exome Sequencing Study of 50 Patients

Philipp A. Greif, Luise Hartmann, Sebastian Vosberg, Sophie M. Stief et autres

Somatic variants

Table S3 from Evolution of Cytogenetically Normal Acute Myeloid Leukemia During Therapy and Relapse: An Exome Sequencing Study of 50 Patients

Philipp A. Greif, Luise Hartmann, Sebastian Vosberg, Sophie M. Stief et autres

Somatic variants

Table S4 from Evolution of Cytogenetically Normal Acute Myeloid Leukemia During Therapy and Relapse: An Exome Sequencing Study of 50 Patients

Philipp A. Greif, Luise Hartmann, Sebastian Vosberg, Sophie M. Stief et autres

Mutation profile of the cell lines MM-1 and MM-6

Table S1 from Evolution of Cytogenetically Normal Acute Myeloid Leukemia During Therapy and Relapse: An Exome Sequencing Study of 50 Patients

Philipp A. Greif, Luise Hartmann, Sebastian Vosberg, Sophie M. Stief et autres

Summary patient characteristics

Table S2 from Evolution of Cytogenetically Normal Acute Myeloid Leukemia During Therapy and Relapse: An Exome Sequencing Study of 50 Patients

Philipp A. Greif, Luise Hartmann, Sebastian Vosberg, Sophie M. Stief et autres

Detailed patient characteristics

Supplementary Figures from Evolution of Cytogenetically Normal Acute Myeloid Leukemia During Therapy and Relapse: An Exome Sequencing Study of 50 Patients

Philipp A. Greif, Luise Hartmann, Sebastian Vosberg, Sophie M. Stief et autres

Figure S1 Recurrently mutated genes and comparison to TCGA cohort. Figure S2 Stabililty of recurrently mutated genes over disease course. Figure S3 Variant allele frequency plots from diagnosis to relapse for each individual patient. Figure S4 Mutation patterns of individual genes. Lines …