Tao Zhuang

Drug−Drug Salts of Rucaparib with Nonsteroidal Anti-Inflammatory Drugs: Crystal Structures, Intermolecular Interactions, Solubility Enhancement, and Antitumor Activity

Can Wang, Shuo Liu, Jiyang Zhang, Wenjing Gao et autres

Abstract Rucaparib (RUCA) is an orally administered PARP inhibitor with an important clinical value in cancer therapy, but its poor aqueous solubility remains a major challenge for improving its dissolution behavior and pharmaceutical performance. In this study, drug−drug salt formation was adopted …

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Discovery of Nanocrystalline Drug–Drug Salts of Vortioxetine with Diclofenac or ( S )-Flurbiprofen as Long-Acting Antidepressant Formulations

Jie Song, Yangyang Song, Jiyang Zhang, Can Wang et autres

Abstract Depression is a prevalent and serious mental disorder that constitutes a major global public health challenge. However, due to the complex pathogenesis of depression, traditional antidepressants usually suffer from some limitations such as low efficacy and the need for frequent administration. …

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Design and synthesis of long-acting prodrugs of SEP-363856 with sustained antipsychotic-like activity

Wenjing Gao, Yunlin Xue, Jiyang Zhang, Haoyun Chen et autres

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Targeting P2X receptors for analgesia: Small molecule antagonists in development

Zhibin He, XJ Huang, Fengchun He, Ying huang et autres

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Discovery of novel N-(alkylpiperidinyl) substituted benzamides targeting the glycine transporter 2 with anti-nociceptive effects in neuropathic pain

Xingyu Yao, Xiaomin Han, Ziying Li, Wenjing Gao et autres

cn (code pays fourni par la source)

Discovery of 3-indolealkylamines as novel dual-target σ1R/H3R ligands with potent analgesia

Xiong Chen, Zong-Zheng Li, Xiaoyan Yao, Xiaomin Han et autres

A new drug-drug co-amorphous system of imipramine and celecoxib with improved solubility and synergistic antinociceptive effects

Zhiling Chen, Huiling Zhou, Jie SONG, Ben Xu et autres

New drug-drug salts of palbociclib and nonsteroidal anti-inflammatory drugs with enhanced physicochemical properties and antitumor activities

Zhiling Chen, Mingyue Zhang, Jie Ding, Can Wang et autres

Corrigendum to “Novel drug-drug co-amorphous systems of olaparib with nonsteroidal anti-inflammatory drugs with improved solubility, physical stability, antitumor activity and pharmacokinetics” [J. Drug Deliv. Sci. and Technol. 106232]

Zheng-Kang Luo, Hui‐Min Qin, Jin-Meng Han, Jin Zhu et autres

Discovery of a long-acting nanocrystal formulation of INND-2201, a new co-drug of pregabalin and palmitoylethanolamide with synergistic analgesic effects

Xiaomin Han, Yang Xiao, Chao-Nan Huang, Ming-Yue Yin et autres

Chronic pain is a global health problem affecting approximately 30% of the adult population worldwide. Currently available painkillers often showed limited efficacy or serious adverse effects and require frequent administration to maintain therapeutic effects. To develop new long-acting analgesics with synergistic antinociceptive …

Synthesis, structural characterization, in silico ADMET analysis and quality control of a new process-related impurity in vortioxetine

Xi Yao, Xiong Chen, Wenjing Gao, Haoyun Chen et autres

Discovery of two new co-drugs of celecoxib and gabapentinoids for treating chemotherapy-induced peripheral neuropathy

Mingyue Yin, Xinyi Xiao, Yang Sean Xiao, Jingyan Zhou et autres