2023
conference-abstract
OpenAlex
Jesse Green, Andrew Tucker, Aesha Vakil, Matt Scott-Skandera et autres
Fusosomes are viral vectors pseudotyped with modified paramyxovirus envelopes targeting specific cell types. A CD8-targeted fusosome delivering a CD19CAR transgene has the potential to provide an off-the-shelf therapeutic approach to generate in vivo CD19-directed chimeric antigen receptor (CAR) T cells in patients. …
us
(code pays fourni par la source)
2023
conference-abstract
OpenAlex
Jesse Green, Brian Granger, Ouwen Liang, Jesus Moreno et autres
Abstract Introduction: Fusosomes are viral vectors pseudotyped with modified paramyxovirus envelopes targeting specific cell types. A CD8-targeted fusosome delivering CD19CAR transgene has the potential to provide an off-the-shelf therapeutic approach to generate CD19-directed chimeric antigen receptor (CAR) T cells in patients after …
us
(code pays fourni par la source)
2021
conference-abstract
OpenAlex
Justine J. Cunningham, Sundeep Chandra, Akinola Olumide Emmanuel, Allyse Mazzarelli et autres
Abstract Introduction: Ex vivo manufactured chimeric antigen receptor (CAR) T cell therapies are highly effective for treating B cell malignancies. However, the complexity, cost and time required to manufacture CAR T cells limits access. To overcome conventional ex vivo CAR T limitations, …
us
(code pays fourni par la source)