Accès ouvert
2025
article
OpenAlex
Kevin Gori, Adrian Baez‐Ortega, Andrea Strakova, Maximilian R. Stammnitz et autres
Horizontal transfer of nuclear DNA between cells of host and cancer is a potential source of adaptive variation in cancer cells. An understanding of the frequency and significance of this process in naturally occurring tumors is, however, lacking. We screened for this …
gb, in, ar, gd, br, au, dk, cn, co, jp, np, py
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Accès ouvert
2024
preprint
OpenAlex
Kevin Gori, Adrian Baez‐Ortega, Andrea Strakova, Maximilian R. Stammnitz et autres
Summary Although somatic cell genomes are usually entirely clonally inherited, nuclear DNA exchange between cells of an organism can occur sporadically by cell fusion, phagocytosis or other mechanisms 1–3 . This phenomenon has long been noted in the context of cancer, where …
gb, ar, gd, br, Nigéria, uy, co, bt, ro, py
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Accès ouvert
2020
article
OpenAlex
Andrea Strakova, Thomas J. Nicholls, Adrian Baez‐Ortega, Máire Ní Leathlobhair et autres
Autonomous replication and segregation of mitochondrial DNA (mtDNA) creates the potential for evolutionary conflict driven by emergence of haplotypes under positive selection for 'selfish' traits, such as replicative advantage. However, few cases of this phenomenon arising within natural populations have been described. …
gb, se, in, cl, pa, gd, Kenya, bz, us, br, Nigéria, ws, ve, gr, pt, Sénégal, nl, uy, it, mx, ec, Ouganda, co, pk, au, ro, tr, py, Malawi
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Accès ouvert
2019
article
OpenAlex
Adrian Baez‐Ortega, Kevin Gori, Andrea Strakova, Janice L. Allen et autres
The canine transmissible venereal tumor (CTVT) is a cancer lineage that arose several millennia ago and survives by "metastasizing" between hosts through cell transfer. The somatic mutations in this cancer record its phylogeography and evolutionary history. We constructed a time-resolved phylogeny from …
gb, in, cl, pa, gd, Kenya, bz, us, br, Nigéria, ws, ve, gr, pt, Sénégal, nl, uy, it, mx, ec, Gambie, Ouganda, co, pk, ua, au, ro, tr, py, Malawi
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Accès ouvert
2016
article
OpenAlex
Andrea Strakova, Máire Ní Leathlobhair, Guodong Wang, Tingting Yin et autres
Canine transmissible venereal tumour (CTVT) is a clonally transmissible cancer that originated approximately 11,000 years ago and affects dogs worldwide. Despite the clonal origin of the CTVT nuclear genome, CTVT mitochondrial genomes (mtDNAs) have been acquired by periodic capture from transient hosts. …
gb, cn, au, us, sr, pa, br, gd, Kenya, bz, mx, Nigéria, ws, ve, ch, cl, pt, Afrique du Sud, uy, fr, it, ec, Gambie, Ouganda, pk, ru, ua, nl, py
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Accès ouvert
2016
peer-review
OpenAlex
Andrea Strakova, Máire Ní Leathlobhair, Guodong Wang, Tingting Yin et autres
Genetics of a canine transmissible tumour show how the world’s oldest cancer “metastasised” through the global dog population – and captured, maintained and rearranged its mitochondrial DNA along the way.
gb, cn, au, sr, pa, ie, br, gd, us, Kenya, bz, Nigéria, ws, ve, ch, hu, es, Afrique du Sud, mx, uy, fr, it, Ouganda, ae, pt, pk, in, ua, py
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