James M. Coghill

A Tacrolimus Population Pharmacokinetic Model for Adult Allogeneic Hematopoietic Cell Transplant Recipients Provides Clinical Opportunities for Precision Dosing

Tyler Dunlap, Jing Zhu, Daniel Weiner, Ryan M. Kemper et autres

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A simple and efficient method for the robust expansion of human ILC2s to prevent acute GVHD

Danny Bruce, Sonia J. Laurie, Yan Xing, Heather E. Stefanski et autres

ABSTRACT: Reconstitution of stem cells and enhancement of the barrier function of the gastrointestinal (GI) tract is critical to the resolution of intestinal acute graft-versus-host disease (aGVHD). Previously, our group has shown in murine models that type 2 innate lymphoid cells (ILC2s) …

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Anti-CD30 CAR T cells as consolidation after autologous haematopoietic stem-cell transplantation in patients with high-risk CD30+ lymphoma: a phase 1 study

Natalie S. Grover, Dominic T. Moore, William A. Wood, Christopher Dittus et autres

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A randomized, placebo‐controlled first‐in‐human study of oral TQS‐168 in healthy volunteers: Assessment of safety, tolerability, pharmacokinetics, pharmacodynamics, and food effect

Jonas Hannestad, Steven Smith, Andrew Lam, Janet Hurt et autres

Abstract TQS‐168, a first‐in‐class small‐molecule inducer of peroxisome proliferator‐activated receptor gamma coactivator 1‐alpha gene expression, is in development for the treatment of amyotrophic lateral sclerosis. A single‐ascending‐dose (SAD) and multiple‐ascending‐dose (MAD) study of TQS‐168 was carried out in healthy male subjects to …

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Anti-CD30 CAR T cells as consolidation after autologous haematopoietic stem-cell transplantation in patients with high-risk CD30+ lymphoma: a phase 1 study

Natalie S. Grover, George Hucks, Marcie Riches, Anastasia Ivanova et autres

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ALVR106, an Off-the-Shelf, Multivirus-Specific T-Cell Therapy, for the Treatment of Respiratory Viral Infections: Results from a Phase 1, First-in-Human, Dose-Ranging Trial

Sarah Nikiforow, Mitchell Horowitz, John M. McCarty, Anum Abbas et autres

Community-acquired respiratory viruses are leading causes of morbidity and mortality after hematopoietic cell transplant (HCT) or solid organ transplant (SOT). ALVR106, an allogeneic, off-the-shelf, polyclonal, multi-respiratory virus T-cell therapy specific for influenza (Flu), human metapneumovirus (hMPV), parainfluenza virus (PIV), and respiratory syncytial …

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Safety and Efficacy of CD30.CAR-T Cells as Consolidation Post Autologous Transplant in High-Risk CD30 Lymphoma

Natalie S. Grover, George Hucks, Marcie Riches, Anastasia Ivanova et autres

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ALVR106, an Off-the-Shelf, Multivirus-Specific T-Cell Therapy, for the Treatment of Respiratory Viral Infections: Results from a Phase 1, First-in-Human, Dose-Ranging Trial

Sarah Nikiforow, Mitchell E. Horwitz, John M. McCarty, Anum Abbas et autres

Background: Community-acquired respiratory viruses such as influenza (Flu), human metapneumovirus (hMPV), parainfluenza virus (PIV), and respiratory syncytial virus (RSV) are leading causes of morbidity and mortality after hematopoietic cell transplant (HCT) or solid organ transplant (SOT). While these viruses may begin in …

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Data from Peptide/MHC Tetramer–Based Sorting of CD8+ T Cells to a Leukemia Antigen Yields Clonotypes Drawn Nonspecifically from an Underlying Restricted Repertoire

Sally A. Hunsucker, Colleen S. McGary, Benjamin G. Vincent, Atim A. Enyenihi et autres

Abstract Testing of T cell–based cancer therapeutics often involves measuring cancer antigen–specific T-cell populations with the assumption that they arise from in vivo clonal expansion. This analysis, using peptide/MHC tetramers, is often ambiguous. From a leukemia cell line, we identified a CDK4-derived …

Supplementary Tables 1 - 4, Figures 1 - 2 from Peptide/MHC Tetramer–Based Sorting of CD8+ T Cells to a Leukemia Antigen Yields Clonotypes Drawn Nonspecifically from an Underlying Restricted Repertoire

Sally A. Hunsucker, Colleen S. McGary, Benjamin G. Vincent, Atim A. Enyenihi et autres

The document contains 4 supplemental tables: 1. RT-PCR Primers for TCRbeta sequencing 2. HPLC-MS identified peptide sequences 3. The amino acid sequences of recurrent TCRbeta clonotypes 4. The distribution of the CDR3 amino acid length in the analyzed patient. There are 2 …

Supplementary Tables 1 - 4, Figures 1 - 2 from Peptide/MHC Tetramer–Based Sorting of CD8+ T Cells to a Leukemia Antigen Yields Clonotypes Drawn Nonspecifically from an Underlying Restricted Repertoire

Sally A. Hunsucker, Colleen S. McGary, Benjamin G. Vincent, Atim A. Enyenihi et autres

The document contains 4 supplemental tables: 1. RT-PCR Primers for TCRbeta sequencing 2. HPLC-MS identified peptide sequences 3. The amino acid sequences of recurrent TCRbeta clonotypes 4. The distribution of the CDR3 amino acid length in the analyzed patient. There are 2 …

Data from Peptide/MHC Tetramer–Based Sorting of CD8+ T Cells to a Leukemia Antigen Yields Clonotypes Drawn Nonspecifically from an Underlying Restricted Repertoire

Sally A. Hunsucker, Colleen S. McGary, Benjamin G. Vincent, Atim A. Enyenihi et autres

Abstract Testing of T cell–based cancer therapeutics often involves measuring cancer antigen–specific T-cell populations with the assumption that they arise from in vivo clonal expansion. This analysis, using peptide/MHC tetramers, is often ambiguous. From a leukemia cell line, we identified a CDK4-derived …