T.O. Kilpeläinen

A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure

S. Debette, Annette Peters, J.M. Norris, M. Kähönen et autres

Genome-wide association analysis advanced understanding of blood pressure (BP), a major risk factor for vascular conditions such as coronary heart disease and stroke. Accounting for smoking behavior may help identify BP loci and extend our knowledge of its genetic architecture. We performed …

Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

J.M. Norris, Εvangelos Εvangelou, C.E. Lewis, André G. Uitterlinden et autres

Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of circulating HDL cholesterol, LDL cholesterol, and triglyceride …

Multi-ancestry genome-wide association study accounting for gene-psychosocial factor interactions identifies novel loci for blood pressure traits

Wei Zheng, Jennifer G. Robinson, M.A. Richard, K. Schwander et autres

Psychological and social factors are known to influence blood pressure (BP) and risk of hypertension and associated cardiovascular diseases. To identify novel BP loci, we carried out genome-wide association meta-analyses of systolic, diastolic, pulse, and mean arterial BP, taking into account the …

Multi-ancestry genome-wide gene–sleep interactions identify novel loci for blood pressure

M.A. Ikram, M. Fornage, J.I. Rotter, Michael R. Brown et autres

Genetic studies of leptin concentrations implicate leptin in the regulation of early adiposity

A.P. Reiner, O.T. Raitakari, A.P. Morris, P.M. Ridker et autres

Leptin influences food intake by informing the brain about the status of body fat stores. Rare LEP mutations associated with congenital leptin deficiency cause severe early-onset obesity that can be mitigated by admin-istering leptin. However, the role of genetic regulation of leptin …

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Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology

K.E. North, J.B. Borja, L.-P. Lyytikäinen, S. Männistö et autres

Circulating levels of adiponectin, an adipocyte-secreted protein associated with cardiovascular and metabolic risk, are highly heritable. To gain insights into the biology that regulates adiponectin levels, we performed an exome array meta-analysis of 265,780 genetic variants in 67,739 individuals of European, Hispanic, …

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