Rochelle Buffenstein

The naked mole-rat microbiome is associated with healthy aging and social structure

Ceylan Tanes, Naomi G. Wilson, Megan Smith, Tanvi T. Patel et autres

The naked mole-rat (NMR), Heterocephalus glaber, is an unusual mammal that lives underground in eusocial colonies. NMRs show remarkable longevity and are resistant to cancer, neurodegeneration, and cardiovascular disease. The gut microbiome is known to modulate human health and disease; here, we …

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Digging deeper into cancer resistance in the extraordinarily long-lived naked mole-rat

Tanvi T. Patel, Vince G. Amoroso, Kaitlyn N. Lewis Hardell, Vikram Narayan et autres

Abstract The naked mole-rat (Bathyergidae; Heterocephalus glaber ) is an extremophilic rodent that lives an extraordinarily long and healthy life despite having evolved in harsh, arid, underground conditions. This ~ 31-million-year evolutionary path and concomitant adaptations have surprisingly yielded a broad suite …

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Supplementary Figure S10 from An Autochthonous Model of Lung Cancer Identifies Requirements for Cellular Transformation in the Naked Mole Rat

Alyssa Shepard, Daniel Lester, Scott Troutman, Sany Hoxha et autres

Analysis of in vivo infections with Tp53 and Rb1 adenoviruses.

Supplementary Table 3 from An Autochthonous Model of Lung Cancer Identifies Requirements for Cellular Transformation in the Naked Mole Rat

Alyssa Shepard, Daniel K. Lester, Scott Troutman, Sany Hoxha et autres

List of BaseScope probes used in study

Supplementary Table 1 from An Autochthonous Model of Lung Cancer Identifies Requirements for Cellular Transformation in the Naked Mole Rat

Alyssa Shepard, Daniel K. Lester, Scott Troutman, Sany Hoxha et autres

List of primers used in studies

Supplementary Methods 1 from An Autochthonous Model of Lung Cancer Identifies Requirements for Cellular Transformation in the Naked Mole Rat

Alyssa Shepard, Daniel K. Lester, Scott Troutman, Sany Hoxha et autres

Supplemental methods and references

Supplementary Figure S8 from An Autochthonous Model of Lung Cancer Identifies Requirements for Cellular Transformation in the Naked Mole Rat

Alyssa Shepard, Daniel K. Lester, Scott Troutman, Sany Hoxha et autres

analysis of Ad-PR infected lungs at 6-months

Supplementary Figure S5 from An Autochthonous Model of Lung Cancer Identifies Requirements for Cellular Transformation in the Naked Mole Rat

Alyssa Shepard, Daniel Lester, Scott Troutman, Sany Hoxha et autres

H&E stained NMR lung tissue from control and Eml4-Alk infections

Supplementary Figure S2 from An Autochthonous Model of Lung Cancer Identifies Requirements for Cellular Transformation in the Naked Mole Rat

Alyssa Shepard, Daniel Lester, Scott Troutman, Sany Hoxha et autres

Assessing NMR adenovirus infections of lungs

Data from An Autochthonous Model of Lung Cancer Identifies Requirements for Cellular Transformation in the Naked Mole Rat

Alyssa Shepard, Daniel Lester, Scott Troutman, Sany Hoxha et autres

Abstract There is growing interest in understanding the mechanisms underlying differences in cancer incidence among species (comparative oncology). The naked mole rat (NMR) is often referenced as “cancer resistant” and prior studies focused on identifying mechanisms explaining this. However, efforts to assess …

Supplementary Figure S11 from An Autochthonous Model of Lung Cancer Identifies Requirements for Cellular Transformation in the Naked Mole Rat

Alyssa Shepard, Daniel Lester, Scott Troutman, Sany Hoxha et autres

Antibody validation against NMR proteins

Supplementary Figure S9 from An Autochthonous Model of Lung Cancer Identifies Requirements for Cellular Transformation in the Naked Mole Rat

Alyssa Shepard, Daniel K. Lester, Scott Troutman, Sany Hoxha et autres

Schematic of Tp53 and Rb1 deletions.