Systematic molecular profiling to identify determinants of response to ibrutinib
Negin Karisani, Amit Sud, Liang Li, Satyen H Gohil et autres
Abstract BACKGROUND Whilst the broad clonal architecture of naturally progressing chronic lymphocytic leukemia (CLL) has been described, a comprehensive picture of how chemotherapy and targeted agents reshape that landscape is lacking. Here we integrate clone-specific growth kinetics with mutational profiles, transcriptomic subtypes, …
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Blood