Julia A. Metcalf

Anti-influenza hyperimmune intravenous immunoglobulin for adults with influenza A or B infection (FLU-IVIG): a double-blind, randomised, placebo-controlled trial

Richard T. Davey, Eduardo Fernández‐Cruz, Norman Markowitz, Abdel G. Babiker et autres

BACKGROUND: Since the 1918 influenza pandemic, non-randomised studies and small clinical trials have suggested that convalescent plasma or anti-influenza hyperimmune intravenous immunoglobulin (hIVIG) might have clinical benefit for patients with influenza infection, but definitive data do not exist. We aimed to evaluate …

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The benefit of immediate compared with deferred antiretroviral therapy on CD4+ cell count recovery in early HIV infection

Shweta Sharma, Katherine Schlusser, Pola de la Torre, Giuseppe Tambussi et autres

OBJECTIVE: To assess the impact of immediate vs. deferred antiretroviral therapy (ART) on CD4 recovery among individuals early in HIV infection. DESIGN: Using serologic markers of early infection together with self-reported dates of infection and HIV diagnosis, ART-naive participants who were randomized …

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Influence of sample collection tube method, anticoagulant-containing plasma versus serum, on influenza virus hemagglutination inhibition titer and microneutralization titer serological assays

Brian J. Morrison, Nicholas J. Martin, Tauseef Ur Rehman, Dan Ewing et autres

BACKGROUND: The hemagglutination-inhibition (HAI) assay is a critical component for measurement of immunogenicity in influenza vaccine development. It is unknown if the results can be influenced by sample type and anticoagulants. The purpose of this study was to evaluate the influence of …

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Using Clinical Research Networks to Assess Severity of an Emerging Influenza Pandemic

Lone Simonsen, Elizabeth S. Higgs, Robert J. Taylor, Deborah Wentworth et autres

Background: Early clinical severity assessments during the 2009 influenza A H1N1 pandemic (pH1N1) overestimated clinical severity due to selection bias and other factors. We retrospectively investigated how to use data from the International Network for Strategic Initiatives in Global HIV Trials, a …

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Comparison of Self-report to Biomarkers of Recent HIV Infection: Findings from the START Trial

Katherine Schlusser, Shweta Sharma, Pola de la Torre, Giuseppe Tambussi et autres

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Additional file 1: of Influence of sample collection tube method, anticoagulant-containing plasma versus serum, on influenza virus hemagglutination inhibition titer and microneutralization titer serological assays

Brian J. Morrison, Nicholas J. Martin, Tauseef Ur Rehman, Dan Ewing et autres

HAI and MN Titer Values. HAI and MN titer values for all influenza types for the thirty matched samples and for the six collection tube methods. (XLSX 27 kb)

Increased Indoleamine-2,3-Dioxygenase Activity Is Associated With Poor Clinical Outcome in Adults Hospitalized With Influenza in the INSIGHT FLU003Plus Study

Sarah Pett, Ken M. Kunisaki, Deborah Wentworth, Timothy J. Griffin et autres

Abstract Background Indoleamine-2,3-dioxygenase (IDO) mediated tryptophan (TRP) depletion has antimicrobial and immuno-regulatory effects. Increased kynurenine (KYN)-to-TRP (KT) ratios, reflecting increased IDO activity, have been associated with poorer outcomes from several infections. Methods We performed a case-control (1:2; age and sex matched) analysis …

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Immune plasma for the treatment of severe influenza: an open-label, multicentre, phase 2 randomised study

Pablo Tebas, Marie‐Carmelle Elie, Ednan K. Bajwa, Todd E Bell et autres

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Comparison of the Outcomes of Individuals With Medically Attended Influenza A and B Virus Infections Enrolled in 2 International Cohort Studies Over a 6-Year Period: 2009–2015

Ruth Lynfield, Marcelo Losso, Richard T. Davey, Alessandro Cozzi‐Lepri et autres

Abstract Background Outcome data from prospective follow-up studies comparing infections with different influenza virus types/subtypes are limited. Methods Demographic, clinical characteristics and follow-up outcomes for adults with laboratory-confirmed influenza A(H1N1)pdm09, A(H3N2), or B virus infections were compared in 2 prospective cohorts enrolled …

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Systemic Inflammation, Coagulation, and Clinical Risk in the START Trial

Jason V. Baker, Shweta Sharma, Birgit Grund, Adam Rupert et autres

BACKGROUND: The Strategic Timing of AntiRetroviral Treatment (START) trial demonstrated that immediate (at CD4+ >500 cells/µL) vs deferred (to CD4+ <350 cells/µL or AIDS) antiretroviral therapy (ART) initiation reduced risk for AIDS and serious non-AIDS (SNA). We investigated associations of inflammation, coagulation, …

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Interleukin-15 (IL-15) Strongly Correlates with Increasing HIV-1 Viremia and Markers of Inflammation

Sanjay Swaminathan, Ju Qiu, Adam Rupert, Zonghui Hu et autres

OBJECTIVE: IL-15 has been postulated to play an important role in HIV-1 infection, yet there are conflicting reports regarding its expression levels in these patients. We sought to measure the level of IL-15 in a large, well characterised cohort of HIV-1 infected …

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The effects of storage temperature on PBMC gene expression

Jun Yang, Joseph W. Adelsberger, Xueyuan Zhou, Randy Stevens et autres

BACKGROUND: Cryopreservation of peripheral blood mononuclear cells (PBMCs) is a common and essential practice in conducting research. There are different reports in the literature as to whether cryopreserved PBMCs need to only be stored ≤ -150 °C or can be stored for …

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