S. Francioso

SAT-608-YI Genetic diversification in hepatitis Delta antigen and ribozyme correlates with altered virological and biochemical markers and may inform novel therapeutic targets

Alessia Magnapera, Lorenzo Piermatteo, Tylla Annamuhammedova, Lavinia Fabeni et autres

OS-076-YI Long-read sequencing unveils extensive HBV-DNA integration driving massive HBsAg production and sustaining HDV persistence

Stefano D’Anna, Lorenzo Piermatteo, Ilaria Grossi, Giuseppina Brancaccio et autres

Chronic HDV Infection Shows Higher HBsAg Isoform Levels than HBV Infection, Paralleling HDV Replicative Activity

Stefano D’Anna, Lorenzo Piermatteo, Alessia Magnapera, Ilaria Grossi et autres

BACKGROUND & AIM: The entry of Hepatitis D Virus (HDV) depends on HBV surface proteins (HBsAg) composed of three isoforms: large-, middle, and small HBsAg. Here, we investigate the levels of total HBsAg and HBsAg isoforms and their correlations with HDV-RNA, HBcrAg, …

it (code pays fourni par la source)

OC24 An increased genetic variability characterises HDV sub-genotypes 1 and can drive the selection of divergent genetic pathways modulating HDV replicative potential and cytolytic activity

L. Piermatteo, Agesilao Magnapera, G. Torre, Luca Carioti et autres

OC48 HBV integration can sustain intrahepatic HDV activity and can modulate HBV pathogenetic potential

Silvestro Ennio D’Anna, L. Piermatteo, Andrea Di Lorenzo, Luca Carioti et autres

OS-072-YI HBV integration can sustain HDV persistence especially in the setting of an absent HBV reservoir and can be a biomarker of response to bulevirtide

Stefano D’Anna, Lorenzo Piermatteo, Andrea Di Lorenzo, Luca Carioti et autres

SAT-292-YI In HDV sub-genotypes 1, the high degree of genetic variability can drive the selection of divergent genetic pathways modulating HDV replicative potential and cytolytic activity

Lorenzo Piermatteo, Giulia Torre, Luca Carioti, Stefano D’Anna et autres

A high degree of genetic variability characterises HDV sub-genotypes 1 and can drive the selection of divergent genetic pathways modulating HDV replicative potential and cytolytic activity.

Lorenzo Piermatteo, Giulia Torre, Luca Carioti, Stefano D’Anna et autres

An increased genetic variability characterises HDV sub-genotypes 1 and can drive the selection of divergent genetic pathways modulating HDV replicative potential and cytolytic activity

Lorenzo Piermatteo, Giulia Torre, Luca Carioti, Stefano D’Anna et autres

FRI-392-YI Chronic HDV coinfection (CHD) is characterized by a more elevated production of Middle and Large HBsAg than HBV monoinfection, that parallels HDV replicative and cytolytic activity

Lorenzo Piermatteo, Stefano D’Anna, Antonella Olivero, Leonardo Duca et autres

OS-094 Chronic HDV infection is sustained by an intense HBsAg production fromintegrated HBV-DNA in the setting of a limited or even absent HBV reservoir

Romina Salpini, Stefano D’Anna, Lorenzo Piermatteo, Giuseppina Brancaccio et autres

SC-5 HDV persistence is sustained by HBsAg mainly derived from integrated HBV-DNA and is independent from the extent of HBV reservoir

Silvestro Ennio D’Anna, L. Piermatteo, Gabriella Brancaccio, Emanuele Teti et autres

Background HDV exploits HBV surface glycoproteins (HBsAg) for viral morphogenesis and infectivity. Here, we investigate HBV and HDV activities and their interplay in liver biopsies from patients (pts) with chronic HDV infection (CHD) and HBV monoinfection (CHB). Methods 68 HBeAg-negative pts (75% …

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