Antonio Cassone

State-of-the-Art Review: Managing Vulvovaginal Candidiasis

Riina Rautemaa-Richardson, J. D. Sobel, Neil Stone, Francesco De Seta et autres

Vulvovaginal candidiasis is one of the most prevalent infections in women worldwide. Together with its recurrent form, it affects millions of women annually, causing significant symptoms and severely impacting quality of life. This review examines the pathophysiology, risk factors, microbiome interactions, clinical …

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The Glycan Ectodomain of SARS-CoV-2 Spike Protein Modulates Cytokine Production and Expression of CD206 Mannose Receptor in PBMC Cultures of Pre-COVID-19 Healthy Subjects

Cristiana Barbati, Carla Bromuro, Silvia Vendetti, Antonella Torosantucci et autres

The ability of recombinant, SARS-CoV-2 Spike (S) protein to modulate the production of two COVID-19 relevant, pro-inflammatory cytokines (IL-6 and IFN-γ) in PBMC cultures of healthy, pre-COVID-19 subjects was investigated. We observed that cytokine production was largely and diversely modulated by the …

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The Glycan Ectodomain of SARS-Cov-2 Spike Protein Modulates Cytokine Production and Expression of CD206 Mannose Receptor in PBMC Cultures of Pre-COVID-19 Healthy Subjects

Cristiana Barbati, Carla Bromuro, Silvia Vendetti, Antonella Torosantucci et autres

The ability of recombinant, SARS-CoV-2 Spike (S) protein to modulate the production of two COVID-19 relevant, pro-inflammatory cytokines (IL-6 and IFN-γ) in PBMC cultures of healthy, pre-Covid-19 subjects was investigated. We observed that cytokine production was largely and diversely modulated by the …

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Mycobacterium tuberculosis antigen 85B modifies BCG-induced antituberculosis immunity and favors pathogen survival

Giovanni Piccaro, Gabriella Aquino, Vincenzo Gigantino, Valentina Tirelli et autres

Tuberculosis is one of the deadliest infectious diseases worldwide. Mycobacterium tuberculosis has developed strategies not only to evade host immunity but also to manipulate it for its survival. We investigated whether Mycobacterium tuberculosis exploited the immunogenicity of Ag85B, one of its major …

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Identification of two anti- Candida antibodies associated with the survival of patients with candidemia

Carla Bromuro, Brunella Posteraro, Rita Murri, Massimo Fantoni et autres

ABSTRACT We retrospectively studied antibody immunity in 92 candidemia patients, using sera taken at candidemia diagnosis. All patients showed the presence of IgG antibodies against all tested Candida antigens, namely Als3, Mp65, Hyr1 and Eno1, at levels significantly higher than those of …

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Molecular In-Depth on the Epidemiological Expansion of SARS-CoV-2 XBB.1.5

Fabio Scarpa, Ilenia Azzena, Chiara Locci, Marco Casu et autres

Since the beginning of the pandemic, the generation of new variants periodically recurs. The XBB.1.5 SARS-CoV-2 variant is one of the most recent. This research was aimed at verifying the potential hazard of this new subvariant. To achieve this objective, we performed …

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Genome‐based comparison between the recombinant SARS‐CoV‐2 XBB and its parental lineages

Fabio Scarpa, Daria Sanna, Ilenia Azzena, Marco Casu et autres

Recombination is the main contributor to RNA virus evolution, and SARS-CoV-2 during the pandemic produced several recombinants. The most recent SARS-CoV-2 recombinant is the lineage labeled XBB, also known as Gryphon, which arose from BJ.1 and BM.1.1.1. Here we performed a genome-based …

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Genetic and structural genome-based survey reveals the low potential for epidemiological expansion of the SARS-CoV-2 XBB.1.5 sublineage

Fabio Scarpa, Elena Imperia, Ilenia Azzena, Marta Giovanetti et autres

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Genome-based comparison between the recombinant SARS-CoV-2 XBB and its parental lineages

Fabio Scarpa, Daria Sanna, Ilenia Azzena, Marco Casu et autres

Abstract Recombination is the main contributor to RNA virus evolution, and SARS-CoV-2 during the pandemic produced several recombinants. The most recent SARS-CoV-2 recombinant is the lineage labeled XBB, also known as Gryphon, which arose from BJ.1 and BM. 1.1.1. Here we performed …

it, br (code pays fourni par la source)

Genetic and Structural Data on the SARS-CoV-2 Omicron BQ.1 Variant Reveal Its Low Potential for Epidemiological Expansion

Fabio Scarpa, Daria Sanna, Domenico Benvenuto, Alessândra Borsetti et autres

The BQ.1 SARS-CoV-2 variant, also known as Cerberus, is one of the most recent Omicron descendant lineages. Compared to its direct progenitor BA.5, BQ.1 has some additional spike mutations in some key antigenic sites, which confer further immune escape ability over other …

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Genetic and structural data on the SARS-CoV-2 Omicron BQ.1 variant reveal its low potential for epidemiological expansion

Fabio Scarpa, Daria Sanna, Domenico Benvenuto, Alessândra Borsetti et autres

Abstract The BQ.1 SARS-CoV-2 variant, also known as Cerberus, is one of the most recent Omicron descendant lineages. Compared to its direct progenitor BA.5, BQ.1 carries out some additional spike mutations in some key antigenic site which confer it further immune escape …

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Peculiar Variations of the Electrostatic Potential of Spike Protein N-terminal Domain Associated with the Emergence of Successive SARS-CoV-2 Omicron Lineages

Stefano Pascarella, Massimo Ciccozzi, Domenico Benvenuto, Alessândra Borsetti et autres

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