Roman Wennauer

An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans

Eleftheria Zeggini, Karl Gertow, Veikko Salomaa, John D. Eicher et autres

To characterise type 2 diabetes (T2D) associated variation across the allele frequency spectrum, we conducted a meta-analysis of genome-wide association data from 26,676 T2D cases and 132,532 controls of European ancestry after imputation using the 1000 Genomes multi-ethnic reference panel. Promising association …

An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans.

Robert A. Scott, Laura J. Scott, Letizia Marullo, Kyle J. Gaulton et autres

To characterize type 2 diabetes (T2D)-associated variation across the allele frequency spectrum, we conducted a meta-analysis of genome-wide association data from 26,676 T2D case and 132,532 control subjects of European ancestry after imputation using the 1000 Genomes multiethnic reference panel. Promising association …

An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans

Robert A. Scott, Laura J. Scott, Reedik Mägi, Letizia Marullo et autres

To characterize type 2 diabetes (T2D)-associated variation across the allele frequency spectrum, we conducted a meta-analysis of genome-wide association data from 26,676 T2D case and 132,532 control subjects of European ancestry after imputation using the 1000 Genomes multiethnic reference panel. Promising association …

gb, us, ee, it, dk, is, cn, se, de, nl, fr, fi, sg (code pays fourni par la source)

Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

Thomas W. Winkler, Anne E. Justice, Mariaelisa Graff, Llilda Barata et autres

[This corrects the article DOI: 10.1371/journal.pgen.1005378.].

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.

Kyle J. Gaulton, Teresa Ferreira, Yeji Lee, Anne Raimondo et autres

We performed fine mapping of 39 established type 2 diabetes (T2D) loci in 27,206 cases and 57,574 controls of European ancestry. We identified 49 distinct association signals at these loci, including five mapping in or near KCNQ1. 'Credible sets' of the variants …

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

Kyle J. Gaulton, Teresa Ferreira, Yeji Lee, Anne Raimondo et autres

gb, us, ee, dk, fr, de, se, fi, is, nl, it, sg, no (code pays fourni par la source)

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

Thomas W. Winkler, Anne E. Justice, Mariaelisa Graff, Llilda Barata et autres

Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these …

us, se, dk, gb, ch, de, nl, fr, ca, au, fi, is, it, mv, be, at (code pays fourni par la source)

New genetic loci link adipose and insulin biology to body fat distribution

Dmitry Shungin, Thomas W. Winkler, Damien C. Croteau‐Chonka, Teresa Ferreira et autres

se, de, us, gb, ee, ru, dk, ch, nl, au, fi, fr, it, ph, no (code pays fourni par la source)

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

Thomas W. Winkler, Anne E Justice, Mariaelisa Graff, Llilda Barata et autres

Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these …

Defining the role of common variation in the genomic and biological architecture of adult human height.

Andrew R. Wood, Tõnu Esko, Jian Yang, Sailaja Vedantam et autres

Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in independent studies, we show that the most strongly associated ∼2,000, ∼3,700 and …

gb, ee, au, us, se, ch, nl, ca, it, de, dk, fi, fr, ie, no (code pays fourni par la source)

Defining the role of common variation in the genomic and biological architecture of adult human height

Andrew R. Wood, Tõnu Esko, Jian Yang, Sailaja Vedantam et autres

gb, ee, au, us, se, ch, nl, ca, it, de, dk, fi, fr, ie, no (code pays fourni par la source)

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

Anubha Mahajan, Min Jin Go, Weihua Zhang, Jennifer E. Below et autres

To further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we aggregated published meta-analyses of genome-wide association studies (GWAS), including 26,488 cases and 83,964 controls of European, east Asian, south Asian and Mexican and Mexican American ancestry. We observed …