Suchira Bose

The Relationship between p-tau217, p-tau231, and p-tau205 in the Human Brain Is Affected by the Cellular Environment and Alzheimer’s Disease Pathology

Malin Wennström, Nina Schultz, Paula Mille Gallardo, Geidy E. Serrano et autres

The levels of p-tau217 and p-tau231 in cerebrospinal fluid (CSF) are associated with early amyloid beta (Aß) changes in the brain, while the CSF levels of p-tau205 are foremost related to tau pathology in the later stages of the disease. To investigate …

se, nl, us, gb (code pays fourni par la source)

Synaptic Release of Pathological Tau Is Calcium- and SNAP25-Dependent, and Blocked by BoNT-A Activity

Anna Masato, Chiara Panzi, Ioana Butnaru, Laura Restani et autres

gb, it (code pays fourni par la source)

Synaptic alterations associated with disrupted sensory encoding in a mouse model of tauopathy

S. Meftah, Annalisa Cavallini, Tracey K. Murray, Łukasz Jankowski et autres

Abstract Synapse loss is currently the best biological correlate of cognitive decline in Alzheimer’s disease and other tauopathies. Synapses seem to be highly vulnerable to tau-mediated disruption in neurodegenerative tauopathies. However, it is unclear how and when this leads to alterations in …

gb (code pays fourni par la source)

Synaptic alterations associated with disrupted sensory encoding in a mouse model of tauopathy

S. Meftah, Annalisa Cavallini, Tracey K. Murray, Łukasz Jankowski et autres

Abstract Synapse loss is currently the best biological correlate of cognitive decline in Alzheimer’s disease and other tauopathies. Synapses seem to be highly vulnerable to tau-mediated disruption in neurodegenerative tauopathies. However, it is unclear how and when this leads to alterations in …

gb (code pays fourni par la source)

Mechanism of action deconvolution of the small-molecule pathological tau aggregation inhibitor Anle138b

Layla Hosseini-Gerami, Elena Ficulle, Neil Humphryes-Kirilov, David Airey et autres

BACKGROUND: A key histopathological hallmark of Alzheimer's disease (AD) is the presence of neurofibrillary tangles of aggregated microtubule-associated protein tau in neurons. Anle138b is a small molecule which has previously shown efficacy in mice in reducing tau aggregates and rescuing AD disease …

gb, us, au, es (code pays fourni par la source)

Additional file 2 of Mechanism of action deconvolution of the small-molecule pathological tau aggregation inhibitor Anle138b

Layla Hosseini-Gerami, Elena Ficulle, Neil Humphryes-Kirilov, David Airey et autres

Additional file 2. Full details of OpenTargets Tauopathies and Alzheimer's Disease association scores of each DEG in each experiment.

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Additional file 5 of Mechanism of action deconvolution of the small-molecule pathological tau aggregation inhibitor Anle138b

Layla Hosseini-Gerami, Elena Ficulle, Neil Humphryes-Kirilov, David Airey et autres

Additional file 5. Full matrix of target predictions.

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Additional file 1 of Mechanism of action deconvolution of the small-molecule pathological tau aggregation inhibitor Anle138b

Layla Hosseini-Gerami, Elena Ficulle, Neil Humphryes-Kirilov, David Airey et autres

Additional file 1. RNA-Seq results from Anle138b perturbation experiments on rat cortical neuron (RCN) cells, with their Log2FC and adjusted p-values.

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Additional file 3 of Mechanism of action deconvolution of the small-molecule pathological tau aggregation inhibitor Anle138b

Layla Hosseini-Gerami, Elena Ficulle, Neil Humphryes-Kirilov, David Airey et autres

Additional file 3. All enriched pathways and their associated adjusted p-values.

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Additional file 4 of Mechanism of action deconvolution of the small-molecule pathological tau aggregation inhibitor Anle138b

Layla Hosseini-Gerami, Elena Ficulle, Neil Humphryes-Kirilov, David Airey et autres

Additional file 4. Upstream regulators inferred from causal reasoning across different algorithms/networks and the frequency of their occurrence.

gb, us, ca, es, de (code pays fourni par la source)

Metabotropic Glutamate Receptors Modulate Exocytotic Tau Release and Propagation

Francesca Mazzo, Ioana Butnaru, Olivera Grubisha, Elena Ficulle et autres

us, gb (code pays fourni par la source)

A human tau seeded neuronal cell model recapitulates molecular responses associated with Alzheimer’s disease

Elena Ficulle, Sarubini Kananathan, David Airey, Severine Gharbi et autres

Cellular models recapitulating features of tauopathies are useful tools to investigate the causes and consequences of tau aggregation and the identification of novel treatments. We seeded rat primary cortical neurons with tau isolated from Alzheimer's disease brains to induce a time-dependent increase …

gb, us, es (code pays fourni par la source)