Profil bibliographique

Philippe Dugay

Informations fournies par OpenAlex. Research Africa ne déduit ni nationalité, ni poste, ni coordonnées personnelles.

2Publications signalées
75Citations signalées
1Affiliations récentes

Les institutions déclarées

Sanofi (France)

Les domaines associés

Alzheimer's disease research and treatmentsGlycosylation and Glycoproteins ResearchMonoclonal and Polyclonal Antibodies ResearchNeuroinflammation and Neurodegeneration MechanismsAdvanced Biosensing Techniques and Applications

Les publications récentes

Accès ouvert 2020 article OpenAlex

Tetravalent Bispecific Tandem Antibodies Improve Brain Exposure and Efficacy in an Amyloid Transgenic Mouse Model

Tuan-Minh Do, Cécile Capdevila, Laurent Pradier, Véronique Blanchard et autres

Most antibodies display very low brain exposure due to the blood-brain barrier (BBB) preventing their entry into brain parenchyma. Transferrin receptor (TfR) has been used previously to ferry antibodies to the brain by using different formats of bispecific constructs. Tetravalent bispecific tandem …

fr, de (code pays fourni par la source)

31 citations Molecular Therapy — Methods & Clinical Development
Accès ouvert 2018 article OpenAlex

SAR228810: an antibody for protofibrillar amyloid β peptide designed to reduce the risk of amyloid-related imaging abnormalities (ARIA)

Laurent Pradier, Véronique Blanchard-Brégeon, Andrees Bohme, Thomas Debeir et autres

BACKGROUND: Anti-amyloid β (Aβ) immunotherapy represents a major area of drug development for Alzheimer's disease (AD). However, Aβ peptide adopts multiple conformations and the pathological forms to be specifically targeted have not been identified. Aβ immunotherapy-related vasogenic edema has also been severely …

fr, us, jp (code pays fourni par la source)

44 citations Alzheimer s Research & Therapy
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