Accès ouvert
2025
other
OpenAlex
Dorothy L. Hallberg, Alice C. Eastman, Shashikant Koul, Daniel C. Bruhm et autres
Abstract Endometrioid and mucinous ovarian carcinomas represent nearly a fifth of ovarian cancers, but their molecular characteristics and pathologic origins are poorly understood. To identify the genomic and epigenomic alterations characteristic of these ovarian cancer subtypes and evaluate links to morphologically similar …
Accès ouvert
2025
supplementary-materials
OpenAlex
Dorothy L. Hallberg, Alice C. Eastman, Shashikant Koul, Daniel C. Bruhm et autres
Kaplan-Meier survival curves for ovarian cancer patients with and without mutations in the PI3K and WNT pathways. (a, b) Alterations in the PI3K pathway trended towards increased survival among patients with ovarian endometrioid carcinomas and decreased survival among patients with ovarian mucinous …
Accès ouvert
2025
other
OpenAlex
Dorothy L. Hallberg, Alice C. Eastman, Shashikant Koul, Daniel C. Bruhm et autres
Comparison of mutation frequencies across histologic subtypes in commonly altered genes. A, For known cancer driver genes with an alteration frequency of at least 10% in patients with ovarian or uterine endometrioid cancer, we compared the proportion of samples with alterations between …
Accès ouvert
2025
other
OpenAlex
Dorothy L. Hallberg, Alice C. Eastman, Shashikant Koul, Daniel C. Bruhm et autres
Integrated genomic analyses of ovarian and uterine endometrioid adenocarcinomas. Integrated analyses of somatic point mutations, structural variants, including linked amplicons, deletions, and rearrangements, organized by pathways. The top of the figure shows the number of each type of alteration, the middle portion …
Accès ouvert
2025
other
OpenAlex
Dorothy L. Hallberg, Alice C. Eastman, Shashikant Koul, Daniel C. Bruhm et autres
WGS analyses of linked amplicons and rearrangements. A, Circos plots for linked amplicons for individual tumor samples with >100 structural variants. Circos plots depict copy number alterations as well as intra- and inter-chromosomal rearrangements. Segmented normalized estimates of read depth were used …
Accès ouvert
2025
supplementary-materials
OpenAlex
Dorothy L. Hallberg, Alice C. Eastman, Shashikant Koul, Daniel C. Bruhm et autres
Mutations in ESR1 at Tyr537 and Leu536. ESR1 mutations identified in two patients with uterine endometrioid carcinomas occurred at Tyr537, a hotspot most commonly associated with aromatase inhibitor resistance in patients with breast cancer patients, and Leu536. This hotspot is in close …
Accès ouvert
2025
supplementary-materials
OpenAlex
Dorothy L. Hallberg, Alice C. Eastman, Shashikant Koul, Daniel C. Bruhm et autres
Circos plots of uterine endometrioid carcinoma samples.
Accès ouvert
2025
supplementary-materials
OpenAlex
Dorothy L. Hallberg, Alice C. Eastman, Shashikant Koul, Daniel C. Bruhm et autres
Relationship between tumor purity and number of somatic mutations. (a) Tumor purity for multiple histological tumor types were estimated using FACETS. Samples that FACETS did not process due to undetectable copy number changes are marked with an x. (b) Patients with uterine …
Accès ouvert
2025
other
OpenAlex
Dorothy L. Hallberg, Alice C. Eastman, Shashikant Koul, Daniel C. Bruhm et autres
Integrated genomic analyses of ovarian and colorectal mucinous cancers. Integrated analyses of somatic point mutations, structural variants, including linked amplicons, deletions, and rearrangements, organized by pathways. The top of the figure shows the number of each type of alteration, the middle portion …
Accès ouvert
2025
other
OpenAlex
Dorothy L. Hallberg, Alice C. Eastman, Shashikant Koul, Daniel C. Bruhm et autres
Ovarian endometrioid carcinomas are epigenetically similar to healthy uterine endometrium, whereas ovarian mucinous carcinomas are mixed with both mucinous- and endometrial-like signatures. A, We trained a LD model for the classification of samples as stomach mucinous, colorectal mucinous, or uterine endometrial from …
Accès ouvert
2025
supplementary-materials
OpenAlex
Dorothy L. Hallberg, Alice C. Eastman, Shashikant Koul, Daniel C. Bruhm et autres
Summary of ovarian, uterine, and GI tumors analyzed through whole exome and whole genome analyses.
Accès ouvert
2025
supplementary-materials
OpenAlex
Dorothy L. Hallberg, Alice C. Eastman, Shashikant Koul, Daniel C. Bruhm et autres
Heatmap of methylation values in mucinous and endometrial histotypes. (a) Methylation levels (Betas) at 945 CpG sites having the highest variance across 164 TCGA patient samples that included 77 colorectal mucinous tumors, 37 stomach mucinous tumors, and 46 uterine endometrial samples from …