Annika Nelde

t2pmhc: A Structure-Informed Graph Neural Network to predict TCR-pMHC Binding

Mark Polster, Josua Stadelmaier, Raphaël Gottardi, Elias Ball et autres

Added Quickstart section in the README: a runnable end-to-end example using pre-computed TCRdock structures in the example/ directory, letting users verify their installation and see the expected input/output format without running structure prediction Prerequisites section in the README documenting the Docker (recommended) …

t2pmhc: A Structure-Informed Graph Neural Network to predict TCR-pMHC Binding

Mark Polster, Josua Stadelmaier, Raphaël Gottardi, Elias Ball et autres

Added Quickstart section in the README: a runnable end-to-end example using pre-computed TCRdock structures in the example/ directory, letting users verify their installation and see the expected input/output format without running structure prediction Prerequisites section in the README documenting the Docker (recommended) …

t2pmhc: A Structure-Informed Graph Neural Network to predict TCR-pMHC Binding

Mark Polster, Josua Stadelmaier, Raphaël Gottardi, Elias Ball et autres

v1.1.1 - Covalent Cacau Added CITATION.cff with software citation metadata

Deep learning enables direct HLA typing from immunopeptidomics data

Matteo Pilz, Jonas Scheid, Alina Bauer, Steffen Lemke et autres

The immune system eliminates malignant and infected cells through T-cell-mediated recognition of peptides presented by human leukocyte antigen molecules. Mass spectrometry-based immunopeptidomics enables unbiased identification of naturally presented HLA-restricted peptides and has become central to the development of T-cell-based immunotherapies. However, immunopeptidomics …

de (code pays fourni par la source)

t2pmhc: A Structure-Informed Graph Neural Network to predict TCR-pMHC Binding

Mark Polster, Josua Stadelmaier, Elias Ball, Jonas Scheid et autres

Mapping of T cell receptors (TCRs) to their cognate MHC-presented peptides (pMHC) is central for the development of precision immunotherapies and vaccine design. However, accurate prediction of TCR affinity to peptide antigens remains an open challenge. Most approaches rely solely on sequence …

de (code pays fourni par la source)

t2pmhc: A Structure-Informed Graph Neural Network to Predict TCR-pMHC Binding

Mark Polster, Josua Stadelmaier, Jonas Scheid, Jens Bauer et autres

Personalised multipeptide-based T-cell activator for chronic lymphocytic leukaemia: an open-label, single-centre, phase 1 study

Jonas S. Heitmann, Yacine Maringer, Susanne Jung, Marcel Wacker et autres

BACKGROUND: Therapeutic T-cell activation to induce tumour-specific immune responses promises sustainable cancer control. However, this treatment is not yet widely used because of the challenges of personalised drug design and a shortage of mutation-derived neoepitopes. This study aimed to evaluate the immunogenicity, …

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1239 Uncovering the dark side of the immunopeptidome

Marcel Wacker, Steffen Lemke, Jens Bauer, Jonas Scheid et autres

Background The immune system targets cancer cells through T cell-mediated recognition of antigenic peptides presented on human leucocyte antigen (HLA) molecules, which is the basis of T cell-based immunotherapies. Their success highly depends on the identification of suitable HLA-presented tumor antigens which …

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FLT3-ITD Induces CMTM6 and Enhances Immune Escape in Acute Myeloid Leukemia

Melissa Zwick, Bastian Zinkel, Corinna Spohr, Tamina Rückert et autres

FMS-like tyrosine kinase-3 internal tandem duplication (FLT3-ITD) mutations are frequent in acute myeloid leukemia (AML) and are associated with a high risk of relapse. CKLF-like MARVEL transmembrane domain containing member 6 (CMTM6) stabilizes PD-L1 surface expression and modulates tumor immunity in solid …

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Exceptional tumor-free survival of a patient with metastatic intrahepatic cholangiocarcinoma after surgery and personalized peptide vaccination: revisiting a striking case

Ana Rita R. Maia, J. Schuhmacher, Silvio Nadalin, Alfred Königsrainer et autres

Cholangiocarcinomas are rare but aggressive liver tumors of high lethality with scarce treatment options. Here we report on the follow-up of a patient diagnosed with an intrahepatic cholangiocarcinoma who experienced repeated tumor recurrences including distant metastasis, therefore facing a dismal prognosis. At …

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OP0201 ACHIEVEMENT OF LOW DISEASE ACTIVITY AND REMISSION IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS TREATED WITH DAPIROLIZUMAB PEGOL: 48-WEEK RESULTS FROM A PHASE 3 TRIAL

Eric F. Morand, Lynn M. Carter, Maria Dall’Era, Michelle Petri et autres

Background: Dapirolizumab pegol (DZP) is a novel, polyethylene glycol (PEG)-conjugated antigen-binding fragment (Fab'), lacking an Fc domain. DZP binds CD40L, blocking CD40-CD40L interactions and CD40 activation, and has broad modulatory effects on systemic lupus erythematosus (SLE) immunopathology.[1,2] In the phase 3 PHOENYCS …

au, gb, us, be, ch, de, nl (code pays fourni par la source)

POS0734 DAPIROLIZUMAB PEGOL DEMONSTRATED SIGNIFICANT IMPROVEMENT IN SYSTEMIC LUPUS ERYTHEMATOSUS DISEASE ACTIVITY: EFFICACY AND SAFETY RESULTS OF A PHASE 3 TRIAL

Edward M J Vital, M.E.B. Clowse, David Alan Isenberg, J. Merrill et autres

Background: Dapirolizumab pegol (DZP) is a novel, polyethylene glycol (PEG)-conjugated antigen-binding fragment (Fab'), lacking an Fc domain. DZP binds CD40L, blocking CD40-CD40L interactions and CD40 activation, and has broad modulatory effects on systemic lupus erythematosus (SLE) immunopathology, including reducing B and T …

gb, us, de, au, ch (code pays fourni par la source)