Profil bibliographique

Peter Wessels

Informations fournies par OpenAlex. Research Africa ne déduit ni nationalité, ni poste, ni coordonnées personnelles.

2Publications signalées
166Citations signalées
1Affiliations récentes

Les institutions déclarées

Novartis (Switzerland)

Les domaines associés

Protein Kinase Regulation and GTPase SignalingHippo pathway signaling and YAP/TAZProtein Tyrosine Phosphatases14-3-3 protein interactions

Les publications récentes

2023 conference-abstract OpenAlex

Abstract LB319: IAG933, a selective and orally efficacious YAP1/WWTR1(TAZ)-panTEAD protein-protein interaction inhibitor with pre-clinical activity in monotherapy and combinations

Tobias Schmelzle, Emilie A. Chapeau, Daniel Bauer, Patrick Chêne et autres

Abstract The YAP-TEAD protein-protein interaction (PPI) is a critical event known to mediate YAP oncogenic functions downstream of the Hippo pathway. Current advanced pharmacological agents which aim at inhibiting YAP-TEAD oncogenic function do so by engaging into the lipid pocket of TEAD. …

ch (code pays fourni par la source)

26 citations Cancer Research
Accès ouvert 2022 article OpenAlex

Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C

Andreas Weiss, Edwige Lorthiois, Louise Barys, Kim S. Beyer et autres

Covalent inhibitors of KRASG12C have shown antitumor activity against advanced/metastatic KRASG12C-mutated cancers, though resistance emerges and additional strategies are needed to improve outcomes. JDQ443 is a structurally unique covalent inhibitor of GDP-bound KRASG12C that forms novel interactions with the switch II pocket. …

ch, us, jp (code pays fourni par la source)

140 citations Cancer Discovery
Notice OpenAlex

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