J. A. Castilla

L26/P-027 Single-cell transcriptomic analysis of seminal round cells reveals distinct signatures across non-obstructive azoospermia phenotypes

I. Higueras Serrano, S. González Múñoz, A. Guzmán Jiménez, A. Robles Fernández et autres

Abstract Study question Can deep characterisation of seminal cell transcriptomes from non-obstructive azoospermia (NOA) patients reveal phenotype-specific differences and identify signatures predicting testicular sperm extraction (TESE) outcome? Summary answer Distinct cellular composition and transcriptomic signatures were identified across NOA subtypes, TESE outcome, …

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L26/P-026 Single-cell profiling reveals aberrant germ-cell expression as predictor of TESE failure and identifies targets for regenerative interventions in NOA testes

A. Guzmán-Jiménez, S. González-Muñóz, I. Higueras-Serrano, A. Robles-Fernández et autres

Abstract Study question Can comprehensive single-cell characterisation of germ cells identify molecular predictors of testicular sperm extraction (TESE) outcome and therapeutic targets in patients with non-obstructive azoospermia (NOA)? Summary answer Late-stage germ-cell maturation defects distinguish TESE outcomes, while spermatogonial heterogeneity highlights germ-cell …

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Andrology

M. San Celestino Carchenilla, David Agudo, Sara Rubio, D. Becerra et autres

ANDROLOGY

Jung-Woo Hu, B. K. Seo, Q. V. Neri, Z. Rozenwaks et autres

Introduction: In the last decades sperm DNA quality has been recognized as one of the most important markers of male reproductive potential (Lewis and Aitken, 2005; Ozmen, 2007; Tarozzi, 2007), in contrast to standard semen parameters as sperm density, motility and morphology, …

it (code pays fourni par la source)