Accès ouvert
2026
article
OpenAlex
Anoop Babu Vasandan, Hossam Aly Abdelsamed, Shannon Kathryn Boi, Grace Ward et autres
Abstract Introduction Infants rely heavily on innate immunity while adaptive memory develops. A subset of T cells, termed “virtual memory” or innate-like memory T cells, bridges innate and adaptive immunity, but their emergence in early human life is unclear. Infants receiving gene …
us
(code pays fourni par la source)
2026
article
OpenAlex
Anoop Babu Vasandan, Hossam Abdelsamed, Shannon Boi, Grace A. Ward et autres
Abstract Introduction Infants rely heavily on innate immunity while adaptive memory develops. A subset of T cells, termed “virtual memory” or innate-like memory T cells, bridges innate and adaptive immunity, but their emergence in early human life is unclear. Infants receiving gene …
us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Anoop Babu Vasandan, Hossam Aly Abdelsamed, Shannon K. Boi, Grace A. Ward et autres
Abstract Description The ability to study T cell development in a human model which mimics the establishment of the immune system is a valuable prospect. Our successful gene therapy clinical trial for X-linked severe combined immunodeficiency (SCID-X1) in infants offers such a …
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(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Shruthi Suryaprakash, Yilun Sun, Dinesh Keerthi, Amr Qudeimat et autres
• Risk of acute and chronic GVHD after hematopoietic cell transplantation (HCT) following donor lymphocyte infusion (DLI) is relatively low. • Risk of graft versus host disease increases with shorter duration between HCT and DLI. Donor lymphocyte infusion (DLI) enhances the graft-versus-leukemia …
us
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Accès ouvert
2025
article
OpenAlex
Anoop Babu Vasandan, Hossam Aly Abdelsamed, Shannon Kathryn Boi, Grace Ward et autres
Virtual memory T cells, possessing features of innate immune cells, represent a developmental continuum between innate and adaptive immunity. Here, we describe the genesis of virtual memory T cells during early human life. A longitudinal analysis of peripheral T cells after gene …
us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Swati Naik, Ying Li, Emily Y. Zeng, Subodh Selukar et autres
TCRαβ depletion of haploidentical donor (haplo) grafts allows for low rates of GVHD but delays immune reconstitution (IR) in hematopoietic cell transplant (HCT) recipients. CD45RA-negative (memory) T cells have low alloreactivity, retain specificity for viral antigens, and can enhance IR without risk …
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Accès ouvert
2025
article
OpenAlex
Monica S. Thakar, Brent R. Logan, Xuerong Liu, Elizabeth Dunn et autres
Introduction Incomplete immune correction & graft failure are serious complications that can occur after HCT for SCID , often necessitating additional cellular therapies. Limited information is available about indications, treatment details, or outcomes after subsequent HCTs. Here we provide the largest known …
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(code pays fourni par la source)
2024
conference-abstract
OpenAlex
Swati Naik, Ying Li, Emily Y. Zeng, Subodh Selukar et autres
TCRαβ depletion of haploidentical donor (haplo) grafts allows for low rates of graft-vs-host disease (GVHD) but delays immune reconstitution (IR) in hematopoietic cell transplant (HCT) recipients. Adoptive transfer of donor T cells may enhance IR but is associated with risk of GVHD. …
us
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Swati Naik, Ying Li, Aimee C. Talleur, Subodh Selukar et autres
BACKGROUND: Relapse remains a challenge after transplantation in pediatric patients with hematological malignancies. Myeloablative regimens used for disease control are associated with acute and long-term adverse effects. We used a CD45RA-depleted haploidentical graft for adoptive transfer of memory T cells combined with …
us
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Accès ouvert
2024
article
OpenAlex
Michael Daniel Keller, Patrick J. Hanley, Yueh‐Yun Chi, Paibel Ixia Aguayo-Hiraldo et autres
Viral infections remain a major risk in immunocompromised pediatric patients, and virus-specific T cell (VST) therapy has been successful for treatment of refractory viral infections in prior studies. We performed a phase II multicenter study (NCT03475212) for the treatment of pediatric patients …
us
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Accès ouvert
2024
article
OpenAlex
Rebecca Epperly, Ying Li, Subodh Selukar, Emily Y. Zeng et autres
Patients with hematologic malignancies who relapse after allogeneic hematopoietic cell transplantation (HCT) have a poor prognosis. Although proceeding to subsequent HCT can provide potential for long-term survival, there are limited data to guide which patients are most likely to benefit and which …
us
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Accès ouvert
2024
article
OpenAlex
Shruthi Suryaprakash, Yilun Sun, Li Tang, Dinesh Keerthi et autres
Donor lymphocyte infusion (DLI) is a form of adoptive immunotherapy administered in patients experiencing mixed chimerism (MC) or disease relapse after an allogeneic hematopoietic cell transplantation (HCT). Success is limited by the occurrence of acute and chronic graft-versus-host disease (GVHD). To determine …
us
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