Giovanni Audrey Oswita

Fucosyltransferase 4 shapes oncogenic glycoproteome to drive metastasis of lung adenocarcinoma

Hsuan‐Hsuan Lu, Shu‐Yung Lin, Rueyhung Roc Weng, Yi‐Hsiu Juan et autres

BACKGROUND: Aberrant fucosylation plays a critical role in lung cancer progression. Nevertheless, the key fucosyltransferase with prognostic significance in lung cancer patients, the enzyme's intracellular targets, and complex molecular mechanisms underlying lung cancer metastasis remain incompletely understood. METHODS: We performed a large-scale …

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Fucosyltransferase 4 shapes oncogenic glycoproteome to drive metastasis of lung adenocarcinoma

Hsuan‐Hsuan Lu, Shu‐Yung Lin, Rueyhung Roc Weng, Yi‐Hsiu Juan et autres

Abstract Aberrant fucosylation plays a critical role in lung cancer progression. Identification of the key fucosyltransferase as a therapeutic target may refine lung cancer management. Here, we identified a terminal α1,3-fucosyltransferase, FUT4, as the key prognostic predictor for lung adenocarcinoma through transcriptomic …

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Abstract 1111: Fucosyltransferase 4-mediated aberrant glycosylation and cell signaling networks promote lung cancer metastasis

Hsuan‐Hsuan Lu, Yi‐Hsiu Juan, Rueyhung Roc Weng, Shu‐Yung Lin et autres

Rationale:Aberrant glycosylation has been known to regulate cancer cell trafficking via promoting intravascular adhesion during metastasis. Clinicopathological studies have also shown a strong correlation between aberrant glycosylation and invasive/metastatic potentials of human cancers. However, the major glycosylation enzymes that drive lung cancer …

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Abstract 1111: Fucosyltransferase 4-mediated aberrant glycosylation and cell signaling networks promote lung cancer metastasis

Hsuan‐Hsuan Lu, Yi‐Hsiu Juan, Rueyhung Roc Weng, Shu‐Yung Lin et autres

Abstract Rationale:Aberrant glycosylation has been known to regulate cancer cell trafficking via promoting intravascular adhesion during metastasis. Clinicopathological studies have also shown a strong correlation between aberrant glycosylation and invasive/metastatic potentials of human cancers. However, the major glycosylation enzymes that drive lung …

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Fucosyltransferase 4 Shapes Oncogenic Glycoproteome to Drive Metastasis of Lung Adenocarcinoma

Hsuan‐Hsuan Lu, Shu‐Yung Lin, Rueyhung Roc Weng, Yi‐Hsiu Juan et autres

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