Anwesha Nag

Fusion-driven oncogenic programs shape the immune landscape in translocation renal cell carcinoma

Prathyusha Konda, Alexandra J. Wakolbinger, Y. Cui, Gabriel Roberti De Oliveira et autres

Renal cell carcinomas comprise multiple molecularly distinct cancers but most are treated empirically with therapies designed for clear cell RCC (ccRCC), the most common subtype, due to incomplete understanding of subtype-specific biology. We analyzed single-cell transcriptomes and chromatin accessibility profiles from translocation …

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Metastatic Osteosarcoma is Characterized by Loss of Osteoblastic Lineage Fidelity

Yutaro Tanaka, James J. Morrow, Salvador Casaní-Galdón, Erica M. Pimenta et autres

Osteosarcoma (OS) is a rare and aggressive bone cancer with limited therapeutic progress in several decades. To characterize the transcriptional diversity of malignant cell states in OS, we analyzed single-nucleus RNA sequencing data from 24 tumors, including both primary and metastatic lesions. …

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Investigating the molecular characteristics underlying desmoid tumor clinical trajectory.

Robert Lawrence Dilley, Mushriq Al‐Jazrawe, Ava E. Greenberg, Anthony Anselmo et autres

11583 Background: Desmoid tumors are locally aggressive mesenchymal neoplasms that primarily affect adolescents and young adults. They demonstrate a range of clinical behavior from spontaneous regression to refractory growth leading to morbidity and sometimes mortality. However, there are no prognostic biomarkers for …

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Abstract B025: Fusion-driven oncogenic programs shape the immune landscape in translocation renal cell carcinoma

Prathyusha Konda, Cary N. Weiss, Y. Cui, Sayed Matar et autres

Abstract Renal cell carcinoma (RCC) comprises a diverse group of tumors with varied molecular drivers and clinical outcomes. Despite this heterogeneity, most therapeutic approaches are based on the biology of clear cell RCC (ccRCC), the most prevalent subtype, leaving rarer subtypes such …

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Abstract B057: Decoding tumor microenvironment and resistance following immune checkpoint inhibition therapy in anaplastic thyroid carcinoma

Kartik Sehgal, Kevin Bi, Theodora Pappa, Justine A. Barletta et autres

Abstract Purpose: The vast majority of patients with anaplastic thyroid carcinoma (ATC) without BRAF V600E mutations have limited therapeutic options. We sought to investigate why only a third of ATC patients have tumor responses to immune checkpoint inhibition (ICI) with dual anti-programmed …

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Epigenetic dysregulation of metabolic programs mediates liposarcoma cell plasticity

Erica Pimenta, Amanda Garza, Sabrina Y. Camp, Jihye Park et autres

Sarcomas are rare cancers thought to arise from aberrant mesenchymal stem cell (MSC) differentiation. Liposarcoma (LPS) is among the most commonly diagnosed sarcomas and provides insights into dysfunctional differentiation through its well- and dedifferentiated subtypes (WDLPS and DDLPS). Despite differences in histology …

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Cellular reprogramming during anti-PD-1 and chemotherapy treatment in early-stage primary hormone receptor-positive breast cancer

Jingxin Fu, Adrienne G. Waks, Erica Pimenta, Breanna Titchen et autres

The efficacy of immune checkpoint inhibitors combined with chemotherapy varies among breast cancer subtypes and is particularly less effective in hormone receptor-positive (HR + ) breast cancers. Here, we analyze pre-, on-, and post-treatment biopsies from 20 female patients with stage II-III …

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Evaluation of single-cell RNA profiling technologies using FFPE, fresh, and frozen ccRCC tumor specimens

Simayijiang Xirenayi, Sabrina Y. Camp, Amanda Garza, Yashika Rustagi et autres

ABSTRACT The application of single-cell transcriptomic approaches has deepened our understanding of tumor heterogeneity, immune dynamics, and molecular programs underlying therapy response. The recent development of fixation-compatible single-cell platforms, such as 10x Genomics Flex, offers the opportunity to profile archived formalin-fixed, paraffin-embedded …

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33fusion derived oncogenic programs shape the immune landscape in translocation renal cell carcinoma

Prathyusha Konda, Cary N. Weiss, Y. Cui, Jinyu Wang et autres

Abstract Background Renal cell carcinoma (RCC) comprises a heterogeneous group of cancers with diverse molecular drivers and clinical behaviors. Despite this diversity, the majority of RCC cases are treated using therapeutic strategies developed for the most common subtype, clear cell RCC (ccRCC), …

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Abstract 1180: Epigenetic dysregulation of IGF1 and PPARG2 in dedifferentiated liposarcoma

Erica Pimenta, Amanda Garza, Sabrina Y. Camp, Jihye Park et autres

Abstract Sarcomas are rare connective tissue cancers thought to arise from aberrant mesenchymal stem cell (MSC) differentiation. Liposarcoma (LPS) is among the most common types of adult sarcoma and holds valuable insights into dysfunctional differentiation given its well- and de-differentiated histologic subtypes …

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Epigenetic dysregulation of metabolic programs mediates liposarcoma cell plasticity

Erica Pimenta, Amanda Garza, Sabrina Y. Camp, Jihye Park et autres

ABSTRACT Sarcomas are rare connective tissue cancers thought to arise from aberrant mesenchymal stem cell (MSC) differentiation. Liposarcoma (LPS) holds valuable insights into dysfunctional differentiation given its well- and dedifferentiated histologic subtypes (WDLPS, DDLPS). Despite well-established differences in histology and clinical behavior, …

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P1.01B.02 The Genomic Landscape of Lung Cancer in Never-Smokers from the Women's Health Initiative

Sitapriya Moorthi, Amy L. Paguirigan, Pushpa Itagi, Ming-Chung Ko et autres

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