Profil bibliographique

Mohammad Moshahid Khan

Informations fournies par OpenAlex. Research Africa ne déduit ni nationalité, ni poste, ni coordonnées personnelles.

140Publications signalées

6155Citations signalées

1Affiliations récentes

Les institutions déclarées

University of Tennessee Health Science Center

Les domaines associés

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatmentsCancer-related Molecular PathwaysBiological Research and Disease StudiesNeurological Disease Mechanisms and Treatments

Les publications récentes

Accès ouvert 2026 supplementary-materials OpenAlex

Supplementary Figure 8 from Ubiquitination of Oncogenic Mutant p53 via Attenuation of Ribosome Biogenesis Machinery Effectively Inhibits Pancreatic Tumor Growth

Mudassier Ahmad, Sahir Sultan Alvi, Haider Ahsan, Carlos Perez et autres

Representative pictures of hematoxylin & eosin (H & E) staining showing the effect of BMH-21 treatment does not pose any cytotoxic effect on the histopathological features of different organs in a mice model of pancreatic cancer, orthotopically xenografted with MIA PaCa-2-Luciferase cells. …

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Accès ouvert 2026 supplementary-materials OpenAlex

Supplementary Figure 7 from Ubiquitination of Oncogenic Mutant p53 via Attenuation of Ribosome Biogenesis Machinery Effectively Inhibits Pancreatic Tumor Growth

Mudassier Ahmad, Sahir Sultan Alvi, Haider Ahsan, Carlos Perez et autres

(A): Ex vivo luminescence imaging of pancreatic tumors excised from orthotopically xenografted with MIA PaCa-2 luciferase cells. (B): Detection of metastasis through ex vivo luminescence imaging of excised organs. Various organs are denoted by different numbers i.e., 1: Liver; 2: heart; 3: …

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Supplementary Tables from Ubiquitination of Oncogenic Mutant p53 via Attenuation of Ribosome Biogenesis Machinery Effectively Inhibits Pancreatic Tumor Growth

Mudassier Ahmad, Sahir Sultan Alvi, Haider Ahsan, Carlos Perez et autres

Contains supplementary tables.

0 citations

Accès ouvert 2026 other OpenAlex

Data from Ubiquitination of Oncogenic Mutant p53 via Attenuation of Ribosome Biogenesis Machinery Effectively Inhibits Pancreatic Tumor Growth

Mudassier Ahmad, Sahir Sultan Alvi, Haider Ahsan, Carlos Perez et autres

Abstract Dysregulated ribosome biogenesis and p53 mutations are known to play oncogenic roles in various cancers, including pancreatic cancer. In this study, we demonstrated the therapeutic potential of BMH-21, a pharmacologic inhibitor of RNA polymerase I, against pancreatic cancer by uncovering a …

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Supplementary Figure 6 from Ubiquitination of Oncogenic Mutant p53 via Attenuation of Ribosome Biogenesis Machinery Effectively Inhibits Pancreatic Tumor Growth

Mudassier Ahmad, Sahir Sultan Alvi, Haider Ahsan, Carlos Perez et autres

(A) Effect of BMH-21 treatment on the body weight of mice in orthotopic xenograft experiment with MIA PaCa-2-Luciferase cells. (B) Effect of BMH-21 treatment on the body weight of mice in orthotopic xenografted with AsPC-1 luciferase cells.

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Accès ouvert 2026 supplementary-materials OpenAlex

Supplementary Figure 5 from Ubiquitination of Oncogenic Mutant p53 via Attenuation of Ribosome Biogenesis Machinery Effectively Inhibits Pancreatic Tumor Growth

Mudassier Ahmad, Sahir Sultan Alvi, Haider Ahsan, Carlos A Diaz Pérez et autres

RPA135 interacts with p53 in PanCa cells but no ubiquitination of RPA135 protein was observed. Capan-2 and AsPC-1 cells treated with BMH-21 (2 µM) or BMH-21 + MG132 (10 µM) were subjected to IP with RPA135 antibody and western blot analysis with …

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Supplementary Figure 9 from Ubiquitination of Oncogenic Mutant p53 via Attenuation of Ribosome Biogenesis Machinery Effectively Inhibits Pancreatic Tumor Growth

Mudassier Ahmad, Sahir Sultan Alvi, Haider Ahsan, Carlos Perez et autres

IHC staining showing that BMH-21 treatment downregulates the expression of RPA194 and the markers of cell proliferation (i.e., Ki-67 and PCNA) in mice, orthotopically xenografted with AsPc-1-luciferase cells. Magnification: 20X; Scale bar: 50µm.

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Accès ouvert 2026 supplementary-materials OpenAlex

Supplementary Figure 3 from Ubiquitination of Oncogenic Mutant p53 via Attenuation of Ribosome Biogenesis Machinery Effectively Inhibits Pancreatic Tumor Growth

Mudassier Ahmad, Sahir Sultan Alvi, Haider Ahsan, Carlos Perez et autres

The bar graphs represent the quantification of the effect of BMH-21 on nucleolar proteins in PanCa cells by Image J. (A) Immunofluorescence (IF) of RPA194 decreases by several folds in Capan-2, MIA PaCa-2 and HPAF-II cells treated with 2µM BMH-21 as compared …

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Supplementary Figure 4 from Ubiquitination of Oncogenic Mutant p53 via Attenuation of Ribosome Biogenesis Machinery Effectively Inhibits Pancreatic Tumor Growth

Mudassier Ahmad, Sahir Sultan Alvi, Haider Ahsan, Carlos Perez et autres

The status of p53 of the various PanCa cells used in the study. Western blotting for the screening of p53 expression using antibodies from different vendors in normal and PanCa cells. Ab-1: Cell Signaling Technologies, Cat. No. 2524 (1:1000); Ab-2: Abcam, Cat. …

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Supplementary Data 1 from Ubiquitination of Oncogenic Mutant p53 via Attenuation of Ribosome Biogenesis Machinery Effectively Inhibits Pancreatic Tumor Growth

Mudassier Ahmad, Sahir Sultan Alvi, Haider Ahsan, Carlos Perez et autres

Contains methodology, supplementary figures, and references.

0 citations

Accès ouvert 2026 supplementary-materials OpenAlex

Supplementary Figure 1 from Ubiquitination of Oncogenic Mutant p53 via Attenuation of Ribosome Biogenesis Machinery Effectively Inhibits Pancreatic Tumor Growth

Mudassier Ahmad, Sahir Sultan Alvi, Haider Ahsan, Carlos Perez et autres

The bar graph shows the frequency of variation in p53 in different cancer samples. The data for this graph was obtained from TP3 database (https://tp53.cancer.gov/prevalence_somatic_stats).

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Accès ouvert 2026 supplementary-materials OpenAlex

Supplementary Figure 2 from Ubiquitination of Oncogenic Mutant p53 via Attenuation of Ribosome Biogenesis Machinery Effectively Inhibits Pancreatic Tumor Growth

Mudassier Ahmad, Sahir Sultan Alvi, Haider Ahsan, Carlos Perez et autres

IC50 values of HPDEC and PanCa cells expressing different WT and mutant p53. BMH-21 was found to be least effective against normal HPDEC (IC50 = 33.4 µM).

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