Natalia Perjakova

Genetic insights into biological mechanisms governing human ovarian ageing

D.F. Gudbjartsson, Francesco Cucca, Cari M. Kitahara, Pascal Guénel et autres

Genetic insights into biological mechanisms governing human ovarian ageing

Katherine S. Ruth, Felix R. Day, Jazib Hussain, Ana Martínez-Marchal et autres

gb, dk, es, cz, us, nl, is, jp, ca, se, it, de, ch, au, ee, fr (code pays fourni par la source)

Genetic insights into the biological mechanisms governing human ovarian ageing

Katherine S. Ruth, Felix R. Day, Jazib Hussain, Ana Martínez-Marchal et autres

Abstract Reproductive longevity is critical for fertility and impacts healthy ageing in women, yet insights into the underlying biological mechanisms and treatments to preserve it are limited. Here, we identify 290 genetic determinants of ovarian ageing, assessed using normal variation in age …

gb, dk, es, us, nl, is, ca, se, it, de, ch, au, ee, fr (code pays fourni par la source)

Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk

Nicholas G. Martin, Daníel F. Guðbjartsson, Teresa Nutile, Renée de Mutsert et autres

The timing of puberty is a highly polygenic childhood trait that is epidemiologically associated with various adult diseases. Using 1000 Genomes Project-imputed genotype data in up to similar to 370,000 women, we identify 389 independent signals (P <5 x 10(-8)) for age …

us, in (code pays fourni par la source)

Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk

Felix R. Day, Deborah J. Thompson, Hannes Helgason, Daniel I. Chasman et autres

John Perry, Ken Ong and colleagues analyze genotype data on ∼370,000 women and identify 389 independent signals that associate with age at menarche, implicating ∼250 genes. Their analyses suggest causal inverse associations, independent of BMI, between puberty timing and risks for breast …

gb, is, us, de, nl, it, se, hr, au, ee, ca, es, ch, dk, fi, fr (code pays fourni par la source)

Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk

Felix R. Day, Deborah J. Thompson, Hannes Helgason, Daniel I. Chasman et autres

The timing of puberty is a highly polygenic childhood trait that is epidemiologically associated with various adult diseases. Using 1000 Genomes Project-imputed genotype data in up to ∼370,000 women, we identify 389 independent signals (P < 5 × 10(-8)) for age at …

Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility

Felix R. Day, Deborah J. Thompson, Hannes Helgason, Daniel I. Chasman et autres

Abstract The timing of puberty is a highly polygenic childhood trait that is epidemiologically associated with various adult diseases. Here, we analyse 1000-Genome reference panel imputed genotype data on up to ~370,000 women and identify 389 independent signals (all P<5×10 −8 ) …

gb, is, us, de, nl, it, se, hr, au, ee, ca, es, ch, dk, fi, fr (code pays fourni par la source)