Hannu Norppa

Objectives and achievements of the HUMN project on its 26th anniversary

Michael Felix Fenech, Nina Holland, Errol Zeiger, Peter Wushou Chang et autres

Micronuclei (MN) are a nuclear abnormality that occurs when chromosome fragments or whole chromosomes are not properly segregated during mitosis and consequently are excluded from the main nuclei and wrapped within nuclear membrane to form small nuclei. This maldistribution of genetic material …

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Chromosome-specific induction of micronuclei and chromosomal aberrations by mitomycin C: Involvement of human chromosomes 9, 1 and 16

Julia Catalán, Hilkka Järventaus, Ghita C.‐M. Falck, C. Moreno et autres

Cytogenetic studies have shown that human chromosomes 1, 9, and 16, with a large heterochromatic region of highly methylated classical satellite DNA, are prone to induction of chromatid breaks and interchanges by mitomycin C (MMC). A couple of studies have indicated that …

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HBM4EU Chromates Study—Genotoxicity and Oxidative Stress Biomarkers in Workers Exposed to Hexavalent Chromium

Ana Maria Tavares, Kukka Aimonen, Sophie Ndaw, Aleksandra Fučić et autres

A study was conducted within the European Human Biomonitoring Initiative (HBM4EU) to characterize occupational exposure to Cr(VI). Herein we present the results of biomarkers of genotoxicity and oxidative stress, including micronucleus analysis in lymphocytes and reticulocytes, the comet assay in whole blood, …

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Biomarkers of nanomaterials hazard from multi-layer data

Vittorio Fortino, Pia Kinaret, Michele Fratello, Angela Serra et autres

There is an urgent need to apply effective, data-driven approaches to reliably predict engineered nanomaterial (ENM) toxicity. Here we introduce a predictive computational framework based on the molecular and phenotypic effects of a large panel of ENMs across multiple in vitro and …

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Effect of Surface Modification on the Pulmonary and Systemic Toxicity of Cellulose Nanofibrils

Kukka Aimonen, Mira Hartikainen, Monireh Imani, Satu P. Suhonen et autres

Cellulose nanofibrils (CNFs) have emerged as sustainable options for a wide range of applications. However, the high aspect ratio and biopersistence of CNFs raise concerns about potential health effects. Here, we evaluated the in vivo pulmonary and systemic toxicity of unmodified (U-CNF), …

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Biomarkers of nanomaterials hazard from multi-layer data

Vittorio Fortino, Pia Kinaret, Michele Fratello, Angela Serra et autres

Abstract There is an urgent need to apply effective, data-driven approaches to reliably predict engineered nanomaterial (ENM) toxicity. Here we introduce a predictive computational framework based on the molecular and phenotypic effects of a large panel of ENMs across multiple in vitro …

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Surface functionalization and size modulate the formation of reactive oxygen species and genotoxic effects of cellulose nanofibrils

Kukka Aimonen, Monireh Imani, Mira Hartikainen, Satu P. Suhonen et autres

BACKGROUND: Cellulose nanofibrils (CNFs) have emerged as a sustainable and environmentally friendly option for a broad range of applications. The fibrous nature and high biopersistence of CNFs call for a thorough toxicity assessment, but it is presently unclear which physico-chemical properties could …

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Genotoxicity of nanomaterials

Julia Catalán, Kirsi Siivola, Kukka Aimonen, Gerard Vales et autres

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Toxicogenomic Profiling of 28 Nanomaterials in Mouse Airways

Pia Kinaret, Joseph Ndika, Marit Ilves, Henrik J. Wolff et autres

Abstract Toxicogenomics opens novel opportunities for hazard assessment by utilizing computational methods to map molecular events and biological processes. In this study, the transcriptomic and immunopathological changes associated with airway exposure to a total of 28 engineered nanomaterials (ENM) are investigated. The …

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Role of Surface Chemistry in the In Vitro Lung Response to Nanofibrillated Cellulose

Kukka Aimonen, Satu P. Suhonen, Mira Hartikainen, Viviana R. Lopes et autres

Wood-derived nanofibrillated cellulose (NFC) has emerged as a sustainable material with a wide range of applications and increasing presence in the market. Surface charges are introduced during the preparation of NFC to facilitate the defibrillation process, which may also alter the toxicological …

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Pulmonary toxicity of synthetic amorphous silica – effects of porosity and copper oxide doping

Niels Hadrup, Kukka Aimonen, Marit Ilves, Hanna Lindberg et autres

Materials can be modified for improved functionality. Our aim was to test whether pulmonary toxicity of silica nanomaterials is increased by the introduction of: a) porosity; and b) surface doping with CuO; and whether c) these modifications act synergistically. Mice were exposed …

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Genotoxicity and cellular uptake of nanosized and fine copper oxide particles in human bronchial epithelial cells in vitro

Kirsi Siivola, Satu P. Suhonen, Mira Hartikainen, Julia Catalán et autres

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