The Discovery of Bridged Benzoazepine Amides as Selective Allosteric Modulators of RIPK1
Joanna L. Chen, Joey L. Methot, Matthew J. Mitcheltree, Andrew J. Musacchio et autres
Receptor-interacting protein kinase 1 (RIPK1) plays an essential role in necroptosis, a form of inflammatory, caspase-independent, programmed cell death. Allosteric inhibitors of RIPK1 have been shown to block necroptotic cell death and thus may offer potential therapeutic opportunities across a range of …
us (code pays fourni par la source)
4 citations
ACS Medicinal Chemistry Letters