Juan Carlos Estrada

Electrode Thermal Profile During Ventricular RF Ablation

Daisuke Togashi, Yumi Katsume, Salah H Alahwany, Giovanni Davogustto et autres

BACKGROUND: Electrode-tissue contact and orientation influence radiofrequency (RF) ablation heating, lesion size, and steam pops, and is not easily assessed. A catheter with 6 distal electrode temperature sensors provides thermal profiles that may help clarify electrode-tissue interactions. OBJECTIVES: The aim of this …

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Genetic evaluation of early-onset atrial fibrillation: impact on patient management

James L. Laws, Mahsima Shabani, Hollie L. Williams, Dakota D. Grauherr et autres

BACKGROUND AND AIMS: Genetic testing is recommended for select patients with atrial fibrillation (AF). The aims of this study were to define the results of genetic evaluation and its therapeutic impact for patients referred to a dedicated AF precision medicine clinic. METHODS: …

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The Misleading QRS Morphology of Scar-Related Ventricular Tachycardia

Yumi Katsume, Daisuke Togashi, Shunsuke Uetake, Salah H. Alahwany et autres

BACKGROUND: The QRS morphology of ventricular tachycardia (VT) reflects the re-entry circuit exit location and helps guide mapping for radiofrequency ablation (RFA). It can be misleading, however, particularly in structural heart disease. OBJECTIVES: The aim of this study was to assess the …

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2-Hydroxybenzylamine for Treatment of Atrial Fibrillation: A First-in-Human Clinical Pilot Trial

Zachary T. Yoneda, Matthew J. O’Neill, Diane M. Crawford, Mingfang Ao et autres

BACKGROUND: Inflammation is a common mechanism for atrial fibrillation (AF). 2-Hydroxybenzylamine (2-HOBA) is a novel therapeutic that scavenges isolevuglandins-a downstream mediator of inflammation and oxidative stress. 2-HOBA is safe and reduces AF in mice, prompting a first-in-human pilot clinical trial. METHODS: Participants …

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The Therapeutic Impact of Genetic Evaluation in an Atrial Fibrillation Precision Medicine Clinic

James L. Laws, Mahsima Shabani, Hollie L. Williams, Dakota D. Grauherr et autres

ABSTRACT Background and Aims Genetic testing is recommended for select patients with atrial fibrillation (AF). The aims of this study were to define the results of genetic evaluation and its therapeutic impact for patients referred to a dedicated AF precision medicine clinic. …

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Clinical Characteristics and Outcomes in Patients With Atrial Fibrillation and Pathogenic TTN Variants

Zain Mohammad Virk, Majd A. El‐Harasis, Zachary T. Yoneda, Katherine C. Anderson et autres

BACKGROUND: TTN encodes a sarcomeric protein called titin. Pathogenic rare variants in TTN are the most common finding in patients with atrial fibrillation (AF) and positive genetic testing. OBJECTIVES: This study sought to define the characteristics and outcomes in patients with AF …

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Ablation for Atrial Fibrillation in Patients With Rare Pathogenic Variants in Cardiomyopathy and Arrhythmia Genes

Majd A. El‐Harasis, Zachary T. Yoneda, Katherine C. Anderson, Fei Ye et autres

BACKGROUND: Patients with rare, pathogenic cardiomyopathy (CM) and arrhythmia variants can present with atrial fibrillation (AF). The efficacy of AF ablation in these patients is unknown. OBJECTIVE: This study tested the hypotheses that: 1) patients with a pathogenic variant in any CM …

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Can Intracardiac Echocardiography Reduce Steam Pops During Half-Normal Saline Irrigated Radiofrequency Ablation?

Kanae Hasegawa, Zachary T. Yoneda, Jose R. Martines-Parachini, Edward Michael Powers et autres

BACKGROUND: Irrigated radiofrequency ablation with half-normal saline can potentially increase lesion size but may increase the risk of steam pops with the risk of emboli or perforation. We hypothesized that pops would be preceded by intracardiac echocardiography (ICE) findings as well as …

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PO-03-064 CLINICAL CHARACTERISTICS AND OUTCOMES IN PATIENTS WITH ATRIAL FIBRILLATION AND PATHOGENIC TTN VARIANTS

Zain Virk, Majd A. El‐Harasis, Zachary T. Yoneda, Katherine Anderson et autres

Recurrence After Atrial Fibrillation Ablation and Investigational Biomarkers of Cardiac Remodeling

Majd A. El‐Harasis, Joseph A. Quintana, Jose Roberto Martinez‐Parachini, Gregory G. Jackson et autres

Background Recurrence after atrial fibrillation (AF) ablation remains common. We evaluated the association between recurrence and levels of biomarkers of cardiac remodeling, and their ability to improve recurrence prediction when added to a clinical prediction model. Methods and Results Blood samples collected …

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Safety of ventricular arrhythmia radiofrequency ablation with half-normal saline irrigation

Kanae Hasegawa, Zachary T. Yoneda, Edward Michael Powers, Kenichi Tokutake et autres

AIMS: Failure of radiofrequency (RF) ablation of ventricular arrhythmias is often due to inadequate lesion size. Irrigated RF ablation with half-normal saline (HNS) has the potential to increase lesion size and reduce sodium delivery to the patient if the same volume of …

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Stroke and Bleeding Risks of Endocardial Ablation for Ventricular Arrhythmias

Kanae Hasegawa, Zachary T. Yoneda, Edward Michael Powers, Kenichi Tokutake et autres

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