Stavros C. Manolagas

OR27-02 The Bone Anabolic Effect Of An Antibody Blocking Oxidized Phospholipids Is Associated With An Increase In Wnt10b In Osteoblasts.

Michela Palmieri, Intawat Nookaew, Maria Jose Schuller-Almeida, Ha‐Neui Kim et autres

Abstract Disclosure: M. Palmieri: None. I. Nookaew: None. M.J. Schuller-Almeida: None. H. Kim: None. T.E. Jospeh: None. S.C. Manolagas: None. C.A. O'Brien: None. E. Ambrogini: None. Oxidized phospholipids containing phosphatidylcholine (PC-OxPLs) are toxic molecules present on oxidized low-density lipoproteins (OxLDL) and apoptotic …

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RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1β- and RNA-dependent co-activator of osteoclast gene expression

Y. Abe, Eric Kofman, Maria Almeida, Zhengyu Ouyang et autres

The nuclear receptor co-repressor (NCoR) complex mediates transcriptional repression dependent on histone deacetylation by histone deacetylase 3 (HDAC3) as a component of the complex. Unexpectedly, we found that signaling by the receptor activator of nuclear factor κB (RANK) converts the NCoR/HDAC3 co-repressor …

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Retraction notice to “Deletion of the scavenger receptor Scarb1 in myeloid cells does not affect bone mass” [Bone 170(2023) 116702]

Michela Palmieri, Teenamol E. Joseph, Charles A. O’Brien, Horacio Gómez-Acevedo et autres

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Retraction: Deletion of the scavenger receptor Scarb1 in osteoblast progenitors does not affect bone mass

Michela Palmieri, Teenamol E. Joseph, Charles A. O’Brien, Horacio Gómez-Acevedo et autres

RETRACTED: Deletion of the scavenger receptor Scarb1 in myeloid cells does not affect bone mass

Michela Palmieri, Teenamol E. Joseph, Charles A. O’Brien, Horacio Gómez-Acevedo et autres

The scavenger receptor class B member 1 (SR-B1 or Scarb1) is a glycosylated cell surface receptor for high density lipoproteins (HDL), oxidized low density lipoproteins (OxLDL), and phosphocholine-containing oxidized phospholipids (PC-OxPLs). Scarb1 is expressed in macrophages and has been shown to have …

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Deletion of the Scavenger Receptor Scarb1 in Myeloid Cells Does Not Affect Bone Mass

Michela Palmieri, Teenamol E. Joseph, Charles A. O’Brien, Horacio Gómez-Acevedo et autres

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RF04 | PSUN313 A Natural Antibody Against Oxidized Phospholipids Improves Glucose Metabolism in Aging Mice

Elena Ambrogini, Michela Palmieri, Teenamol E. Joseph, Horacio Gómez-Acevedo et autres

Abstract Oxidative stress-induced lipid peroxidation generates oxidized phospholipids (OxPL), such as oxidized phosphatidylcholine, that are pro-inflammatory moieties present on oxidized low density lipoproteins and apoptotic cells. OxPL have been implicated in the pathogenesis of cardiovascular, neurological, autoimmune, liver, and lung diseases. It …

Mmp13 deletion in mesenchymal cells increases bone mass and may attenuate the cortical bone loss caused by estrogen deficiency

Filipa Ponte, Ha‐Neui Kim, Aaron Warren, Srividhya Iyer et autres

Abstract The protective effect of estrogens against cortical bone loss is mediated via direct actions on mesenchymal cells, but functional evidence for the mediators of these effects has only recently begun to emerge. We report that the matrix metalloproteinase 13 (MMP13) is …

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Deletion of the scavenger receptor Scarb1 in osteoblast progenitors does not affect bone mass

Michela Palmieri, Teenamol E. Joseph, Charles A. O’Brien, Horacio Gómez-Acevedo et autres

The scavenger receptor class B member 1 (SR-B1 or Scarb1) is a cell surface receptor for high density lipoproteins. It also binds oxidized low density lipoproteins and phosphocholine-containing oxidized phospholipids (PC-OxPL), which adversely affect bone homeostasis. Overexpression of a single chain form …

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Mmp13 deletion in mesenchymal cells increases bone mass and attenuates the cortical bone loss caused by estrogen deficiency

Filipa Ponte, Ha‐Neui Kim, Aaron Warren, Srividhya Iyer et autres

Abstract The protective effect of estrogens against cortical bone loss is mediated via direct actions on mesenchymal cells, but functional evidence for the mediators of these effects has only recently begun to emerge. We report that the matrix metalloproteinase 13 (MMP13) is …

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Neutralization of oxidized phospholipids attenuates age‐associated bone loss in mice

Michela Palmieri, Maria Almeida, Intawat Nookaew, Horacio Gómez-Acevedo et autres

Oxidized phospholipids (OxPLs) are pro-inflammatory molecules that affect bone remodeling under physiological conditions. Transgenic expression of a single-chain variable fragment (scFv) of the antigen-binding domain of E06, an IgM natural antibody that recognizes the phosphocholine (PC) moiety of OxPLs, increases trabecular and …

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Mmp-13 deletion in cells of the mesenchymal lineage increases bone mass, decreases endocortical osteoclast number, and attenuates the cortical bone loss caused by estrogen deficiency in mice

Filipa Ponte, Ha‐Neui Kim, Aaron Warren, Srividhya Iyer et autres

Abstract The protective effect of estrogens against cortical bone loss is mediated via direct actions on mesenchymal lineage cells, but functional evidence for the precise molecular mechanism(s) and the mediators of these effects has only recently began to emerge. We report that …

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