Elena Minissale

The PARP14 inhibitor RBN-3143 suppresses lung inflammation in preclinical models

Mario Niepel, Melissa M. Vasbinder, Jennifer R. Molina, Bin Gui et autres

PARP14 is an enzyme of the ADP-ribosyltransferase (ART) family which modifies its substrates by ADP-ribosylation. Published work suggests that PARP14 promotes Th2/Th17 signaling in immune cells by amplifying STAT6- and STAT3-driven transcription, thereby modulating inflammation. PARP14 expression is promoted by interferons and …

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Abstract 2154: PARP7 inhibitor RBN-2397 increases tumoral IFN signaling leading to various tumor cell intrinsic effects and tumor regressions in mouse models

Jennifer R. Molina, Joseph M. Gozgit, Melissa M. Vasbinder, Ryan Abo et autres

Abstract Targeting cytosolic nucleic acid sensing pathways to activate the Type I interferon (IFN) response is an emerging therapeutic strategy being explored in oncology. The PARP family consists of seventeen enzymes that regulate fundamental biological processes including response to cellular stress. PARP7 …

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PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity

Joseph M. Gozgit, Melissa M. Vasbinder, Ryan Abo, Kaiko Kunii et autres

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Abstract 48: RBN-2397: A potent and selective small molecule inhibitor of PARP7 that induces tumor-derived antitumor immunity dependent on CD8 T cells

Joseph M. Gozgit, Melissa M. Vasbinder, Ryan Abo, Kaiko Kunii et autres

Abstract Targeting cytosolic nucleic acid sensing pathways and the Type I interferon (IFN) response is an emerging therapeutic strategy being explored in oncology. The PARP family consists of seventeen enzymes that regulate fundamental biological processes including response to cellular stress. In contrast …

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Abstract 1348: Targeted degradation of PARP14 Using a heterobifunctional small molecule

Tim J. Wigle, Yue Ren, Jennifer R. Molina, Danielle J. Blackwell et autres

Abstract PARP14 is an interferon-stimulated gene that is overexpressed in multiple tumor types and has been shown to promote the pro-tumor M2 polarization of macrophages and support Th2/Th17 signaling in models of allergic airway disease. PARP14 is a large 203 kDa protein …

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A potent and selective PARP14 inhibitor decreases protumor macrophage gene expression and elicits inflammatory responses in tumor explants

Laurie B. Schenkel, Jennifer R. Molina, Kerren K. Swinger, Ryan Abo et autres

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Abstract 1038: A potent and selective PARP14 inhibitor decreases pro-tumor macrophage function and elicits inflammatory responses in tumor explants

Laurie B. Schenkel, Jennifer R. Molina, Kerren K. Swinger, Ryan Abo et autres

Abstract PARPs (poly-ADP-ribose polymerases) are a family of enzymes that regulate a wide variety of important cellular processes including cellular stress signaling pathways implicated in inflammation and cancer. PARP14 is a member of the monoPARP sub-family of PARPs, which catalyze transfer of …

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