Christine Dufès

Transferrin-conjugated, camptothecin-bearing dendrimersomes entrapping docetaxel as a dual-drug nanoplatform for targeted prostate cancer therapy

Musa Albatsh, Zainab Muthanna Hameed Al-Quraishi, Partha Laskar, Sukrut Somani et autres

Background/Objectives: Advanced prostate cancer remains difficult to treat because docetaxel, although clinically important, is limited by systemic toxicity, poor tumor selectivity, and acquired resistance. Camptothecin is a potent anticancer agent, but its clinical application is restricted by poor solubility and instability. This …

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Transferrin-Conjugated, Camptothecin-Bearing Dendrimersomes Entrapping Docetaxel as a Dual-Drug Nanoplatform for Targeted Prostate Cancer Therapy

Musa Albatsh, Zainab Al-Quraishi, Partha Laskar, Sukrut Somani et autres

Background/Objectives: Advanced prostate cancer remains difficult to treat because docetaxel, although clinically important, is limited by systemic toxicity, poor tumor selectivity, and acquired resistance. Camptothecin is a potent anticancer agent, but its clinical application is restricted by poor solubility and instability. This …

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Camptothecin-Bearing PEGylated Polypropylenimine Dendriplexes for Prostate Cancer Gene Therapy: Impact of Microfluidic Processing on Physicochemical Properties and Transfection

Zainab Al-Quraishi, Hawraa Ali-Jerman, Partha Laskar, Ashish Muglikar et autres

Background/Objectives: Prostate cancer is the most commonly diagnosed cancer in men and a leading cause of cancer-related mortality, highlighting the need for delivery systems capable of efficiently transporting both chemotherapeutic drugs and therapeutic genes to tumor cells. Generation-3 diaminobutyric polypropylenimine (DAB) dendrimers …

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PEGylated Zein Micelles for Prostate Cancer Therapy: Influence of PEG Chain Length and Transferrin Targeting on Docetaxel Delivery

Khadeejah Maeyouf, Jitkasem Meewan, Hawraa Ali-Jerman, Musa Albatsh et autres

Background/Objectives: Docetaxel is a widely used chemotherapeutic agent for several malignancies and is an established treatment for castration-resistant prostate cancer. However, its poor aqueous solubility, systemic toxicity, and the emergence of drug resistance limit its clinical benefit. Zein, a prolamin, forms micelles …

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Intravenous Delivery of Angiopep-Functionalized Polypropylenimine Dendriplex Enhances Gene Expression in the Brain

Hawraa Ali-Jerman, Sukrut Somani, Zainab Al-Quraishi, Khadeejah Maeyouf et autres

Background: The application of gene therapy for treating neurological disorders, including brain cancer, Parkinson's, and Alzheimer's disease, is significantly limited by the current shortage of gene vectors that can effectively cross the blood-brain barrier (BBB) following intravenous administration. Recent studies demonstrated that …

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Publisher Correction: On the issue of transparency and reproducibility in nanomedicine

Fanny Caputo, Peter Wick, Betty Y.S. Kim, Chuanbin Mao et autres

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Publisher Correction: On the issue of transparency and reproducibility in nanomedicine

Lars Michael Skjolding, Mauro Ferrari, Danielle M. Charron, Patrick Boisseau et autres

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Enhancing Transfection Efficacy in Glioma Cells: A Comparison of Microfluidic versus Manual Polypropylenimine Dendriplex Formation

Hawraa Ali-Jerman, Zainab Al-Quraishi, Ashish Muglikar, Yvonne Perrie et autres

Background: Gene therapy is a promising therapeutic approach for treating various disorders by introducing modified nucleic acids to correct cellular dysfunctions or introduce new functions. Despite significant advancements in the field, the effective delivery of nucleic acids remains a challenge, due to …

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On the issue of transparency and reproducibility in nanomedicine

Lang Tran, Ronnie H. Fang, Alke Petri‐Fink, Christopher J. Scott et autres

Following our call to join in the discussion over the suitability of implementing a reporting checklist for bio–nano papers, the community responds.

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Transferrin-Bearing, Zein-Based Hybrid Lipid Nanoparticles for Drug and Gene Delivery to Prostate Cancer Cells

Khadeejah Maeyouf, Intouch Sakpakdeejaroen, Sukrut Somani, Jitkasem Meewan et autres

Gene therapy holds great promise for treating prostate cancer unresponsive to conventional therapies. However, the lack of delivery systems that can transport therapeutic DNA and drugs while targeting tumors without harming healthy tissues presents a significant challenge. This study aimed to explore …

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Preparation of Zein-Based Nanoparticles: Nanoprecipitation versus Microfluidic-Assisted Manufacture, Effects of PEGylation on Nanoparticle Characteristics and Cellular Uptake by Melanoma Cells

Jitkasem Meewan, Sukrut Somani, Jamal Almowalad, Partha Laskar et autres

Background: The manufacture of nanoparticles using manual methods is hampered by its challenging scale-up and poor reproducibility. To overcome this issue, the production of zein nanoparticles entrapping a lipophilic drug model, coumarin-6, by using a microfluidic system was assessed in this study. …

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Lactoferrin- and dendrimer-bearing gold nanocages for stimulus-free DNA delivery to prostate cancer cells

Jamal Almowalad, Partha Laskar, Sukrut Somani, Jitkasem Meewan et autres

Background: The use of gene therapy to treat prostate cancer is hampered by the lack of effective nanocarriers that can selectively deliver therapeutic genes to cancer cells. To overcome this, we hypothesize that conjugating lactoferrin, a tumor-targeting ligand, and the diaminobutyric polypropylenimine …

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