Accès ouvert
2023
article
OpenAlex
Simin Aysel Florescu, Dragos Stanciu, Mihaela Zaharia, Alma Kosa et autres
Importance: The efficacy of vitamin C for hospitalized patients with COVID-19 is uncertain. Objective: To determine whether vitamin C improves outcomes for patients with COVID-19. Design, Setting, and Participants: Two prospectively harmonized randomized clinical trials enrolled critically ill patients receiving organ support …
Accès ouvert
2023
article
OpenAlex
Simin Aysel Florescu, Dragos Stanciu, Mihaela Zaharia, Alma Kosa et autres
IMPORTANCE: Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective: To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS: …
Accès ouvert
2022
article
OpenAlex
Simin Florescu, Delia Stanciu, Mihaela Zaharia, Alma Kosa et autres
Importance: The longer-term effects of therapies for the treatment of critically ill patients with COVID-19 are unknown. Objective: To determine the effect of multiple interventions for critically ill adults with COVID-19 on longer-term outcomes. Design, Setting, and Participants: Prespecified secondary analysis of …
Accès ouvert
2022
article
OpenAlex
Simin Florescu, Delia Stanciu, Mihaela Zaharia, Alma Kosa et autres
Importance: The efficacy of antiplatelet therapy in critically ill patients with COVID-19 is uncertain. Objective: To determine whether antiplatelet therapy improves outcomes for critically ill adults with COVID-19. Design, Setting, and Participants: In an ongoing adaptive platform trial (REMAP-CAP) testing multiple interventions …