Hajime Sakuma

Single-visit cardiac functional assessment by cine CT added to CCTA: segment-level validation of low-dose recirculation timing protocol

Naoki Nagasawa, Satoshi Nakamura, Naoki Hashimoto, Akio Yamazaki et autres

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Abstract 4352302: Differential Pathophysiological Mechanism of Exercise Intolerance in Non-Obese Versus Obese Patients with Heart Failure and Preserved Ejection Fraction

Shiro Nakamori, Naoki Fujimoto, Taku Omori, Keishi Moriwaki et autres

Background: Diffuse myocardial fibrosis contributes to diastolic dysfunction and may impair exercise capacity in patients with heart failure and preserved ejection fraction (HFpEF). However, its impact on exercise intolerance in obese versus non-obese HFpEF phenotypes remains unclear. Methods: We retrospectively identified 38 …

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Tracking MRD in multiple myeloma: Soluble BCMA reflects flow cytometry changes

Masanori Toho, Rikako Tabata, Atsushi Uehara, Naoya Fukuda et autres

Abstract Background: Soluble B-cell maturation antigen (sBCMA) is increasingly recognized as a quantitative biomarker of tumor burden and disease activity in multiple myeloma (MM). However, its cross-sectional correlation with measurable residual disease (MRD) by 8-color multiparameter flow cytometry (MFC) and the concordance …

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Computerized Classification Method for Significant Coronary Artery Stenosis in Whole-Heart Coronary Magnetic Resonance Angiography Images

Takuma Shiomi, Ryohei Nakayama, Masafumi Takafuji, Masaki Ishida et autres

The purpose of this study is to develop a computerized classification method for significant coronary artery stenosis in whole-heart coronary magnetic resonance angiography (WHCMRA) images using a three-dimensional convolutional neural network (CNN) enhanced with attention mechanisms. Our database included 951 segments from …

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Assessing Cardiomyocyte DNA Damage Using Cardiovascular Magnetic Resonance T1 Mapping

Mizuki Ichikawa, Shiro Nakamori, Masaki Ishida, Ryuji Okamoto et autres

BACKGROUND: mapping for assessing DNA damage is uncertain. OBJECTIVES: mapping and cardiomyocyte DNA damage in patients with dilated cardiomyopathy (DCM). METHODS: mapping. DNA damage was assessed via poly(ADP-ribose) quantification in biopsy specimens, alongside collagen volume fraction (CVF) measurement. RESULTS: for an equivalent …

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Interplay Between Epicardial Adipose Tissue and Left Ventricular Stiffness in Heart Failure With Preserved Ejection Fraction

Shiro Nakamori, Taku Omori, Naoki Fujimoto, Masaki Ishida et autres

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Cardiac CT reveals high prevalence of coronary artery disease in esophageal cancer eligible for radiotherapy

Akinori Takada, Satoshi Nakamura, Yutaka Toyomasu, Takamitsu Mase et autres

BACKGROUND: Assessment of cardiac disease before cancer therapy is crucial, as advancements in cancer treatment have led to prolonged survival and an increase in cardiovascular complications. Specifically, esophageal cancer and heart disease share common risk factors, such as smoking and obesity. Radiation …

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Long-term follow-up of intensive chemotherapy followed by reduced-dose and reduced-field irradiation for intracranial germ cell tumor

Akinori Takada, Noriko Ii, Masahiro Hirayama, Hidemi Toyoda et autres

OBJECTIVE The authors analyzed the efficacy of intensive chemotherapy followed by reduced-dose and reduced-field irradiation for intracranial germ cell tumors (GCTs) and evaluated the long-term late effects caused by chemoradiotherapy (CRT). METHODS The authors performed a retrospective study. The subjects were 24 …

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Roles of Valproic Acid in Improving Radiation Therapy for Glioblastoma: a Review of Literature Focusing on Clinical Evidence

Yoshihito Nomoto, Yasufumi Yamashita, Yui Watanabe, Yutaka Toyomasu et autres

Glioblastoma (GBM) is the most common and aggressive type of primary brain neoplasm. The current standard therapy for GBM consists of maximal surgical resection within safe limits, followed by radiation therapy (RT) and chemotherapy with temozolomide. Despite advances in treatment, the prognosis …

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