Profil bibliographique

Erin Sheffels

Informations fournies par OpenAlex. Research Africa ne déduit ni nationalité, ni poste, ni coordonnées personnelles.

64Publications signalées

609Citations signalées

0Affiliations récentes

Les domaines associés

Lung Cancer Treatments and MutationsProtein Kinase Regulation and GTPase SignalingBiochemical and Molecular ResearchPI3K/AKT/mTOR signaling in cancerCancer-related gene regulation

Les publications récentes

Accès ouvert 2026 other OpenAlex

Figure S5 from SOS1 Inhibition Enhances the Efficacy of KRASG12C Inhibitors and Delays Resistance in Lung Adenocarcinoma

Brianna R. Daley, Nancy E. Sealover, Bridget A. Finniff, Jacob M. Hughes et autres

KRASG12C-mutated cell lines show universal G12Ci:SHP2i synergy.

0 citations

Accès ouvert 2026 other OpenAlex

Figure S8 from SOS1 Inhibition Enhances the Efficacy of KRASG12C Inhibitors and Delays Resistance in Lung Adenocarcinoma

Brianna R. Daley, Nancy E. Sealover, Bridget A. Finniff, Jacob M. Hughes et autres

SOS2 expression determines the extent of G12Ci:SOS1i synergy.

0 citations

Accès ouvert 2026 other OpenAlex

Figure S9 from SOS1 Inhibition Enhances the Efficacy of KRASG12C Inhibitors and Delays Resistance in Lung Adenocarcinoma

Brianna R. Daley, Nancy E. Sealover, Bridget A. Finniff, Jacob M. Hughes et autres

SOS2 expression determines the extent of G12Ci:SOS1i synergy.

0 citations

Accès ouvert 2026 other OpenAlex

Figure S20 from SOS1 Inhibition Enhances the Efficacy of KRASG12C Inhibitors and Delays Resistance in Lung Adenocarcinoma

Brianna R. Daley, Nancy E. Sealover, Bridget A. Finniff, Jacob M. Hughes et autres

SOS1 inhibition limits the development of acquired G12Ci resistance.

0 citations

Accès ouvert 2026 other OpenAlex

Figure S7 from SOS1 Inhibition Enhances the Efficacy of KRASG12C Inhibitors and Delays Resistance in Lung Adenocarcinoma

Brianna R. Daley, Nancy E. Sealover, Bridget A. Finniff, Jacob M. Hughes et autres

KRASG12C-mutated cell lines show universal G12Ci:SOS1i synergy in the absence of SOS2.

0 citations

Accès ouvert 2026 other OpenAlex

Figure S6 from SOS1 Inhibition Enhances the Efficacy of KRASG12C Inhibitors and Delays Resistance in Lung Adenocarcinoma

Brianna R. Daley, Nancy E. Sealover, Bridget A. Finniff, Jacob M. Hughes et autres

KRASG12C-mutated cell lines show universal G12Ci:SOS1i synergy in low-serum conditions.

0 citations

Accès ouvert 2026 other OpenAlex

Figure S2 from SOS1 Inhibition Enhances the Efficacy of KRASG12C Inhibitors and Delays Resistance in Lung Adenocarcinoma

Brianna R. Daley, Nancy E. Sealover, Bridget A. Finniff, Jacob M. Hughes et autres

SOS1i synergizes with G12Ci to drive transcriptional changes regulating MAPK signaling.

0 citations

Accès ouvert 2026 other OpenAlex

Figure S19 from SOS1 Inhibition Enhances the Efficacy of KRASG12C Inhibitors and Delays Resistance in Lung Adenocarcinoma

Brianna R. Daley, Nancy E. Sealover, Bridget A. Finniff, Jacob M. Hughes et autres

SOS1i shows dose-dependent inhibition of G12Ci acquired resistance.

0 citations

Accès ouvert 2026 other OpenAlex

Figure S12 from SOS1 Inhibition Enhances the Efficacy of KRASG12C Inhibitors and Delays Resistance in Lung Adenocarcinoma

Brianna R. Daley, Nancy E. Sealover, Bridget A. Finniff, Jacob M. Hughes et autres

G12Ci DTPs show reduced G12Ci engagement after washout.

0 citations

Accès ouvert 2026 other OpenAlex

Figure S11 from SOS1 Inhibition Enhances the Efficacy of KRASG12C Inhibitors and Delays Resistance in Lung Adenocarcinoma

Brianna R. Daley, Nancy E. Sealover, Bridget A. Finniff, Jacob M. Hughes et autres

SOS1i synergizes with G12Ci or MEKi in ALDHhigh cells.

0 citations

Accès ouvert 2026 other OpenAlex

Figure S1 from SOS1 Inhibition Enhances the Efficacy of KRASG12C Inhibitors and Delays Resistance in Lung Adenocarcinoma

Brianna R. Daley, Nancy E. Sealover, Bridget A. Finniff, Jacob M. Hughes et autres

SOS1i synergizes with G12Ci under both 2D and 3D culture conditions.

0 citations

Accès ouvert 2026 other OpenAlex

Figure S10 from SOS1 Inhibition Enhances the Efficacy of KRASG12C Inhibitors and Delays Resistance in Lung Adenocarcinoma

Brianna R. Daley, Nancy E. Sealover, Bridget A. Finniff, Jacob M. Hughes et autres

G12Ci treatment increases aldehyde dehydrogenase activity in LUAD cells.

0 citations

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