Mirjana Kessler

Real-world longitudinal Tissue Microarray Platform within clinical routine for Ovarian Cancer: from Primary Surgery through Recurrence in a large Tertiary-Center Cohort

Fabian BT Kraus, Christina Schramm, Liv Kanja, Dana Beyer et autres

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Low reporting quality limits the contribution of human organ models to COVID-19 research: a systematic review

Maren Huelsemann, Silke Kniffert, Anna Löwa, Morris Baumgardt et autres

BACKGROUND: The COVID-19 pandemic created a unique situation in which researchers repurposed human models of varying complexity to investigate SARS-CoV-2, providing the opportunity to analyse their contribution across organs. METHODS: We conducted a systematic review of 558 studies, divided into pandemic and …

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Low reporting quality limits the contribution of human organ models to COVID-19 research: a systematic review.

Maren Hülsemann, Silke Kniffert, Anna Löwa, Morris Baumgardt et autres

Background The COVID-19 pandemic created a unique situation in which researchers repurposed human models of varying complexity to investigate SARS-CoV-2, providing the opportunity to analyse their contribution across organs.Methods We conducted a systematic review of 558 studies, divided into pandemic and post-pandemic …

Preoperative endocrine treatment response in primary postmenopausal endometrial cancer.

Fabian Trillsch, Sven� Mahner, Angelina Vlaški, Mara Franzl et autres

5619 Background: While preoperative endocrine therapy with letrozole has become an established approach for treatment decisions in estrogen receptor (ER) positive breast cancer, this concept has not been transferred to endometrial cancer so far. We hypothesized that preoperative endocrine treatment response to …

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Eutopic echoes ectopic: organoid-based evidence of shared hormone dysregulation in endometriosis

Juste Cioraityte, Lennard Schröder, Zeinesh Beimenbetova, Anna T. Rückl et autres

BACKGROUND: Endometriosis is a highly prevalent, hormone-driven chronic disease characterized by the growth of endometrial tissue outside the uterine cavity. Despite its impact, the mechanisms underlying the disease’s pathogenesis remain poorly understood. We hypothesized that not only the ectopic endometrium of women …

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Additional file 2 of Eutopic echoes ectopic: organoid-based evidence of shared hormone dysregulation in endometriosis

Juste Cioraityte, Lennard Schröder, Zeinesh Beimenbetova, Anna T. Rückl et autres

Supplementary Material 2.

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Eutopic echoes ectopic: organoid-based evidence of shared hormone dysregulation in endometriosis

Juste Cioraityte, Lennard Schröder, Zeinesh Beimenbetova, Anna T. Rückl et autres

Abstract Background Endometriosis is a highly prevalent, hormone-driven chronic disease characterized by the growth of endometrial tissue outside the uterine cavity. Despite its impact, the mechanisms underlying the disease’s pathogenesis remain poorly understood. We hypothesized that not only the ectopic endometrium of …

de (code pays fourni par la source)

Eutopic echoes ectopic: organoid-based evidence of shared hormone dysregulation in endometriosis

Juste Cioraityte, Lennard Schröder, Zeinesh Beimenbetova, Anna T. Rückl et autres

Abstract Background Endometriosis is a highly prevalent, hormone-driven chronic disease characterized by the growth of endometrial tissue outside the uterine cavity. Despite its impact, the mechanisms underlying the disease’s pathogenesis remain poorly understood. We hypothesized that not only the ectopic endometrium of …

de (code pays fourni par la source)

Additional file 1 of Eutopic echoes ectopic: organoid-based evidence of shared hormone dysregulation in endometriosis

Juste Cioraityte, Lennard Schröder, Zeinesh Beimenbetova, Anna T. Rückl et autres

Supplementary Material 1.

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Additional file 1 of Eutopic echoes ectopic: organoid-based evidence of shared hormone dysregulation in endometriosis

Juste Cioraityte, Lennard Schröder, Zeinesh Beimenbetova, Anna T. Rückl et autres

Supplementary Material 1.

de (code pays fourni par la source)

Additional file 2 of Eutopic echoes ectopic: organoid-based evidence of shared hormone dysregulation in endometriosis

Juste Cioraityte, Lennard Schröder, Zeinesh Beimenbetova, Anna T. Rückl et autres

Supplementary Material 2.

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Abstract 1061: Tumor-informed circulating tumor DNA identifies high-grade serous ovarian cancer patients at highest risk for recurrence despite optimal first-line treatment with primary macroscopic complete resection

Magdalena Postl, Christina Victoria Isabella Tauber, Valentina Glueck, Mira Maria Gliga et autres

Abstract Background: Complete macroscopic tumor resection estimation as visualized by the surgeon is the foremost prognostic factor in high-grade serous ovarian cancer (HGSOC). Objective measures of postoperative molecular residual disease (MRD) are lacking, including serologic and radiologic evaluation. Tumor-informed circulating tumor DNA …

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