Alexander J.R. Bishop

EWSR1::FLI1 promotes neocentromere formation in ewing sarcoma cells

Risa Kitagawa, Ediri E. Metitiri, Bin Yu, Changxian Shen et autres

Ewing sarcoma (EwS) is characterized by chimeric fusions such as EWSR1::FLI1. Chromosome gain or loss is prevalent in EwS, and this chromosome instability (CIN) phenotype correlates with poor treatment outcomes. We previously showed that CENP-A, a centromere-specific histone H3 variant, interacts with …

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Heterogeneous expression of immunotherapy response markers in non-small cell lung cancer with hyperactive NRF2 pathway: PD-L1 and beyond

Karoline Almeida-Lima, Marcelo Falchetti, Bárbara dos Santos, Marina Delgobo et autres

Activating mutations in the NRF2 pathway characterize an aggressive, molecularly distinct subtype of non-small cell lung cancer (NSCLC) associated with poor prognosis and resistance to immune checkpoint inhibitors (ICI). In this study, we used a validated NRF2 transcriptional signature along with a …

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Table S1 from SMARCA4 Loss Increases RNA Polymerase II Pausing and Elevates R-Loops to Inhibit BRCA1-Mediated Repair in Ovarian Cancer

Xianbing Zhu, Zheng Fu, Giulio Aceto, Jonathan St‐Germain et autres

Top 31 compounds identified from the FDA drug screen in BIN-67 cells.

Figure S8 from SMARCA4 Loss Increases RNA Polymerase II Pausing and Elevates R-Loops to Inhibit BRCA1-Mediated Repair in Ovarian Cancer

Xianbing Zhu, Zheng Fu, Giulio Aceto, Jonathan St‐Germain et autres

SMARCA4-deficient cells are sensitive to ATR inhibition

Figure S11 from SMARCA4 Loss Increases RNA Polymerase II Pausing and Elevates R-Loops to Inhibit BRCA1-Mediated Repair in Ovarian Cancer

Xianbing Zhu, Zheng Fu, Giulio Aceto, Jonathan St‐Germain et autres

BioID proximity-labeling identifies the association between SMARCA4 and PAF1C

Figure S9 from SMARCA4 Loss Increases RNA Polymerase II Pausing and Elevates R-Loops to Inhibit BRCA1-Mediated Repair in Ovarian Cancer

Xianbing Zhu, Zheng Fu, Giulio Aceto, Jonathan St‐Germain et autres

Removal of R-Loops in SCCOHT cells confers resistance to PARP inhibitors

Figure S2 from SMARCA4 Loss Increases RNA Polymerase II Pausing and Elevates R-Loops to Inhibit BRCA1-Mediated Repair in Ovarian Cancer

Xianbing Zhu, Zheng Fu, Giulio Aceto, Jonathan St‐Germain et autres

SMARCA4 modulates response to PARP inhibitors

Figure S1 from SMARCA4 Loss Increases RNA Polymerase II Pausing and Elevates R-Loops to Inhibit BRCA1-Mediated Repair in Ovarian Cancer

Xianbing Zhu, Zheng Fu, Giulio Aceto, Jonathan St‐Germain et autres

Differential drug responses of SCCOHT cells and ovarian controls.

Figure S7 from SMARCA4 Loss Increases RNA Polymerase II Pausing and Elevates R-Loops to Inhibit BRCA1-Mediated Repair in Ovarian Cancer

Xianbing Zhu, Zheng Fu, Giulio Aceto, Jonathan St‐Germain et autres

SMARCA4 loss leads BRCA1 recruitment and R-Loop accumulation associated with paused Pol II

Figure S12 from SMARCA4 Loss Increases RNA Polymerase II Pausing and Elevates R-Loops to Inhibit BRCA1-Mediated Repair in Ovarian Cancer

Xianbing Zhu, Zheng Fu, Giulio Aceto, Jonathan St‐Germain et autres

Combination of AZD4573 and talazoparib was effective in targeting SMARCA4/2-deficient ovarian cancer cells and was well-tolerated in mice

Figure S10 from SMARCA4 Loss Increases RNA Polymerase II Pausing and Elevates R-Loops to Inhibit BRCA1-Mediated Repair in Ovarian Cancer

Xianbing Zhu, Zheng Fu, Giulio Aceto, Jonathan St‐Germain et autres

Characterization of the pathogenic variants of SMARCA4 retaining protein expression

Table S5 from SMARCA4 Loss Increases RNA Polymerase II Pausing and Elevates R-Loops to Inhibit BRCA1-Mediated Repair in Ovarian Cancer

Xianbing Zhu, Zheng Fu, Giulio Aceto, Jonathan St‐Germain et autres

The 16 BioID candidate SMARCA4 interactors with FDR <0.01.