Accès ouvert
2026
article
OpenAlex
Wen‐Juei Jeng, Chi-Jen Chu, Apinya Leerapun, Anchalee Avihingsanon et autres
BACKGROUND: This study assessed the safety, efficacy, and immunogenicity of a therapeutic immunization strategy aimed at reaching a functional cure for chronic hepatitis B (CHB), relying on a heterologous prime-boost with viral vectors ChAd155-hIi-HBV and MVA-HBV, combined with sequential or concomitant administration …
tw, th, de, be, cn, hk, es, us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Latif Ndeketa, Valérie Haine, Muriel Debois, Kwaku Poku Asante et autres
Background RTS,S/AS01 E was first introduced within the Malaria Vaccine Implementation Programme in selected areas in Ghana, Kenya, and Malawi. A series of post-introduction observational studies were initiated in these areas to assess RTS,S/AS01 E safety and effectiveness in real-world settings. Here, …
gb, Malawi, be, Ghana, in, Kenya, ca
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Lawrence Osei‐Tutu, Simon Kariuki, Cynthia Lee, Robin Fabre et autres
BACKGROUND: vaccine (RTS,S). All regimens provided substantial protection against clinical malaria in natural exposure settings, over 21 and 32 months of follow-up. Here, we present end-of-study results, after 50 months of follow-up. METHODS: This open-label, randomised controlled trial was conducted at two …
Ghana, Kenya, us, be
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Kwaku Poku Asante, Marie‐Cécile Bozonnat, Miloje Savic, Seth Owusu‐Agyei et autres
BACKGROUND: implementation. Interim results from EPI-MAL-002 up to Oct 5, 2018, were reported previously. Here, we report results from the final analysis of the pre-vaccine introduction study. METHODS: vaccination schedule [ie, a simulated vaccination schedule], with additional visits after the simulated schedule …
Ghana, be, Kenya
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Valérie Haine, Martina Oneko, Muriel Debois, Latif Ndeketa et autres
Background RTS,S/AS01 E has been successfully administered to over two million children since 2019 through the Malaria Vaccine Implementation Programme (MVIP). In this Article, we report the safety results of a study evaluating RTS,S/AS01 E safety and effectiveness in real-world settings. Methods …
be, Kenya, gb, Malawi, Ghana, in
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Aaron M. Samuels, Daniel Ansong, Simon Kariuki, Samuel Adjei et autres
Background Controlled infection studies in malaria-naive adults suggest increased vaccine efficacy for fractional-dose versus full-dose regimens of RTS,S/AS01. We report first results of an ongoing trial assessing different fractional-dose regimens in children, in natural exposure settings. Methods This open-label, phase 2b, randomised …
us, Kenya, Ghana, be
(code pays fourni par la source)