Mark Forrest

Effectiveness and cost-effectiveness of a peer-delivered, relational, harm reduction intervention to improve mental health, quality of life, and related outcomes, for people experiencing homelessness and substance use problems: protocol for the ‘SHARPS’ cluster randomised controlled trial

Tessa Parkes, Hannah Carver, Jennifer Boyd, Seonaidh C. Cotton et autres

BACKGROUND: Those experiencing homelessness and problem substance use find it challenging to access the healthcare and treatment they need. The Supporting Harm Reduction through Peer Support (SHARPS) feasibility study demonstrated that Peer Navigators can help these individuals to improve their service engagement, …

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Assessing clinical and cost effectiveness of total versus partial knee replacement (TOPKAT): 10-year follow-up of a multicentre, randomised controlled trial

David John Beard, David J Beard, Loretta J Davies, Jonathan A Cook et autres

BACKGROUND: The Total or Partial Knee Arthroplasty Trial (TOPKAT) aimed to evaluate the difference between total knee replacement (TKR) and partial (unicompartmental) replacement (PKR) for treatment of late-stage medial compartment knee osteoarthritis. As longevity is a key issue for joint replacement, extended …

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Spirometry to manage asthma in children: study protocol for a randomised controlled trial (SPIROMAC)

Victoria Bell, Nicole Sergenson, Seonaidh C. Cotton, David Emele et autres

BACKGROUND: Asthma affects over 1 million children across the UK, and preventative treatment is guided subjectively by patient symptoms. Spirometry is an objective test of lung function and can be used in children to guide treatment. However, current guidelines do not indicate …

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Four Year Clinical and Cost Effectiveness of Vaginal Pessary Self‐Management Versus Clinic‐Based Care for Pelvic Organ Prolapse ( TOPSY ): Long Term Follow‐Up of a Randomised Controlled Superiority Trial

Carol Bugge, Rohna Kearney, Catherine Susan Best, Kirsteen Goodman et autres

OBJECTIVE: To compare long-term clinical and cost-effectiveness of pessary self-management (SM) with clinic-based care (CBC) for pelvic floor-specific quality of life (QoL). DESIGN: Four-year questionnaire follow-up of trial participants. SETTING: UK pessary clinics. SAMPLE: Responders at 4 years aged ≥ 18 years …

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131 - A randomised controlled trial of the clinical and cost-effectiveness of vaginal pessary self-management vs clinic based care for pelvic organ prolapse: four year follow up data

Carol Bugge, R Kearney, Catherine Best, Helen Mason et autres

The UK resuscitative endovascular balloon occlusion of the aorta in trauma patients with life-threatening torso haemorrhage: the (UK-REBOA) multicentre RCT

Jan Olaf Jansen, Jemma Hudson, Charlotte Kennedy, Claire Cochrane et autres

Background: The most common cause of preventable death after injury is haemorrhage. Resuscitative endovascular balloon occlusion of the aorta is intended to provide earlier, temporary haemorrhage control, to facilitate transfer to an operating theatre or interventional radiology suite for definitive haemostasis. Objective: …

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Effectiveness of conservative management versus laparoscopic cholecystectomy in the prevention of recurrent symptoms and complications in adults with uncomplicated symptomatic gallstone disease (C-GALL trial): pragmatic, multicentre randomised controlled trial

Irfan Ahmed, Jemma Hudson, Karen Innes, Rodolfo A. Hernández et autres

OBJECTIVE: To assess the clinical and cost effectiveness of conservative management compared with laparoscopic cholecystectomy for the prevention of symptoms and complications in adults with uncomplicated symptomatic gallstone disease. DESIGN: Parallel group, pragmatic randomised, superiority trial. SETTING: 20 secondary care centres in …

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Clinical effectiveness of vaginal pessary self-management vs clinic-based care for pelvic organ prolapse (TOPSY): a randomised controlled superiority trial

Suzanne Hagen, Rohna Kearney, Kirsteen Goodman, Catherine Best et autres

Background: Prolapse affects 30-40% of women. Those using a pessary for prolapse usually receive care as an outpatient. This trial determined effectiveness and cost-effectiveness of pessary self-management (SM) vs clinic-based care (CBC) in relation to condition-specific quality of life (QoL). Methods: Parallel-group, …

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Emergency Department Resuscitative Endovascular Balloon Occlusion of the Aorta in Trauma Patients With Exsanguinating Hemorrhage

Jan Olaf Jansen, Jemma Hudson, Claire Cochrane, Graeme MacLennan et autres

Importance: Bleeding is the most common cause of preventable death after trauma. Objective: To determine the effectiveness of resuscitative endovascular balloon occlusion of the aorta (REBOA) when used in the emergency department along with standard care vs standard care alone on mortality …

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Clinical and cost‐effectiveness of pessary self‐management versus clinic-based care for pelvic organ prolapse in women: the TOPSY RCT with process evaluation

Carol Bugge, Suzanne Hagen, Andrew Elders, Helen Mason et autres

Background Pelvic organ prolapse is common, causes unpleasant symptoms and negatively affects women’s quality of life. In the UK, most women with pelvic organ prolapse attend clinics for pessary care. Objectives To determine the clinical effectiveness and cost-effectiveness of vaginal pessary self-management …

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Laparoscopic cholecystectomy versus conservative management for adults with uncomplicated symptomatic gallstones: the C-GALL RCT

Karen Innes, Irfan Ahmed, Jemma Hudson, Rodolfo A. Hernández et autres

Background Gallstone disease is a common gastrointestinal disorder in industrialised societies. The prevalence of gallstones in the adult population is estimated to be approximately 10–15%, and around 80% remain asymptomatic. At present, cholecystectomy is the default option for people with symptomatic gallstone …

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Laparoscopic Cholecystectomy Versus Observation/Conservative Management for Preventing Recurrent Symptoms and Complications in Adults with Uncomplicated Symptomatic Gallstones (C-GALL): A Pragmatic, Multicentre Randomised Controlled Trial

Irfan Ahmed, Jemma Hudson, Karen Innes, Rodolfo A. Hernández et autres

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