Frédérique Michel

An integrative approach for studying immunological variation in an aging population – The Milieu Intérieur follow-up study

Anthony Jaquaniello, Florian Dubois, F. Rahal, Tom Dott et autres

Human immune responses vary across individuals due to both genetic and environmental factors. We previously established the Milieu Intérieur cohort to define boundaries of healthy immune variation and identify their determinants. To evaluate how immune responses change over time and test whether …

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Thymic output in human newborns is shaped by environmental exposures and a common TCRD genetic variant

Ziyang Tan, Camille Kergaravat, Laura Gonzalez, Anette Johnsson et autres

Naïve T cell output from the thymus varies across the human lifespan and is a key determinant of health, differing between individuals by age, sex, and genetics. How thymic output is dynamically regulated early in life in response to initial microbial colonization …

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Demographic and genetic factors shape the epitope specificity of the human antibody repertoire against viruses

Axel Olin, Christian Pou, Anthony Jaquaniello, Jack M. Crook et autres

Antibodies are central to immune defenses. Despite advances in understanding the mechanisms of antibody generation, a comprehensive model of how intrinsic and external factors shape human humoral responses to viruses has been lacking. Here we apply phage immunoprecipitation sequencing to investigate the …

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The influence of environment on bacterial co-abundance in the gut microbiomes of healthy human individuals

Christophe Boetto, Violeta Basten Romero, Léo Henches, Arthur Frouin et autres

The gut microbiome is a complex ecosystem characterized not only by its marginal taxonomic composition but also by its emergent properties. Bacteria develop local interactions to form coherent functional communities, whose effects on health and diseases cannot be predicted from the behavior …

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MicroRNA signatures of CD4+ T cell subsets in healthy and multiple sclerosis subjects determined by small RNA-sequencing

Slobodan Čulina, Pierre‐Henri Commère, Élodie Turc, Axel Jouy et autres

Diverse CD4 + T cell subsets with specialized functions operate at different phases of the immune response. Among these are phenotypically and functionally characterized naïve, central memory (CM), effector memory (EM), and regulatory (Treg) cells. Using small RNA-sequencing, we have profiled miRNAs …

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Smoking changes adaptive immunity with persistent effects

Violaine Saint‐André, Bruno Charbit, Anne Biton, Vincent Rouilly et autres

. However, the variables that drive such differences in cytokine secretion-a crucial component of the host response to immune challenges-remain poorly defined. Here we investigated 136 variables and identified smoking, cytomegalovirus latent infection and body mass index as major contributors to variability …

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Microrna Signatures of Cd4+ T Cell Subsets in Healthy and Multiple Sclerosis Subjects Determined by Small Rna-Sequencing

Slobodan Čulina, Pierre‐Henri Commère, Élodie Turc, Axel Jouy et autres

Central Role of Macrophages and Nucleic Acid Release in Myasthenia Gravis Thymus

Cloé Payet, Axel You, Odessa‐Maud Fayet, Edouard Hemery et autres

Objective Myasthenia gravis (MG) is a neuromuscular disease mediated by antibodies against the acetylcholine receptor (AChR). The thymus plays a primary role in AChR‐MG and is characterized by a type I interferon (IFN) signature linked to IFN‐β. We investigated if AChR‐MG was …

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The immune factors driving DNA methylation variation in human blood

Jacob Bergstedt, Sadoune Ait Kaci Azzou, Kristin Tsuo, Anthony Jaquaniello et autres

Epigenetic changes are required for normal development, yet the nature and respective contribution of factors that drive epigenetic variation in humans remain to be fully characterized. Here, we assessed how the blood DNA methylome of 884 adults is affected by DNA sequence …

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IFN-I inducible miR-3614-5p targets ADAR1 isoforms and fine tunes innate immune activation

Françoise Vuillier, Zhi Li, Iain Black, Melania Cruciani et autres

Regulation of innate immune responses is essential for maintenance of immune homeostasis and development of an appropriate immunity against microbial infection. We show here that miR-3614-5p, product of the TRIM25 host gene, is induced by type I interferon (IFN-I) in several human …

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Early IFNβ secretion determines variable downstream IL-12p70 responses upon TLR4 activation

Céline Posseme, Alba Llibre, Bruno Charbit, Vincent Bondet et autres

The interleukin-12 (IL-12) family comprises the only heterodimeric cytokines mediating diverse functional effects. We previously reported a striking bimodal IL-12p70 response to lipopolysaccharide (LPS) stimulation in healthy donors. Herein, we demonstrate that interferon β (IFNβ) is a major upstream determinant of IL-12p70 …

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The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies

Jérémy Manry, Paul Bastard, Adrian Gervais, Tom Le Voyer et autres

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection fatality rate (IFR) doubles with every 5 y of age from childhood onward. Circulating autoantibodies neutralizing IFN-α, IFN-ω, and/or IFN-β are found in ∼20% of deceased patients across age groups, and in ∼1% of …

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