Giulia Taraboletti

Bone marrow–derived thrombospondin-1 programs tumor cell dormancy via CD47–integrin αvβ3 axis

Elena Carlessi, Patrizia Borsotti, Elena Morlacchi, Elisa Longhi et autres

Dormant disseminated tumor cells are responsible for late metastatic relapses, a current clinical challenge. This study investigates the microenvironmental signals that maintain breast cancer cell quiescence in the bone marrow. 4T1.2-CVp27 cells, engineered to enable quiescence detection, are used to assess the …

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Hijacking client instability to selectively disrupt HSP90-driven glucocorticoid receptor activation

Elisa Longhi, Andrea Magni, Luca Torielli, Giulia Lodigiani et autres

The molecular chaperone HSP90 drives the folding and activation of a broad spectrum of client proteins through dynamic, transient multiprotein assemblies. Although HSP90 has been widely pursued as an anticancer target, ATP-competitive inhibitors can trigger indiscriminate client depletion and protective heat shock …

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TSP-1 interaction with RANK and OPG: implications for bone remodeling and osteolytic bone metastasis

Laura Carminati, Fabio Sangalli, Chiara Urbinati, Elisa Longhi et autres

Excessive bone disruption, driven by upregulation of bone-degrading osteoclasts, occurs in several pathologies, including breast cancer osteolytic bone metastasis, a condition associated with poor prognosis and diminished quality of life for patients. The matricellular protein thrombospondin-1 (TSP-1) plays pleiotropic roles in physiological …

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Abstract 2566: Dissecting PDAC cell-microenvironment interplay in liver metastasis by single cell analysis

Claudia Fioravanti, Arianna Vallerga, Giulia Garattini, Ilaria Craparotta et autres

Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal tumors. Because most PDAC patients are diagnosed with an already advanced and metastatic stage of the disease, only 15% are suitable for surgical intervention. Thus, an improved understanding of the metastatic …

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Fibronectin fragments generated by pancreatic trypsin act as endogenous inhibitors of pancreatic tumor growth

Andrea Resovi, Perla Persichitti, Laura Brunelli, Lucia Minoli et autres

BACKGROUND: The pancreatic microenvironment has a defensive role against cancer but it can acquire tumor-promoting properties triggered by multiple mechanisms including alterations in the equilibrium between proteases and their inhibitors. The identification of proteolytic events, targets and pathways would set the basis …

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Thrombospondin-1 in drug activity and tumor response to therapies

Elisa Longhi, Laura Carminati, Elena Carlessi, Dorina Belotti et autres

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Identification of a novel extracellular inhibitor of FGF2/FGFR signaling axis by combined virtual screening and NMR spectroscopy approach

Katiuscia Pagano, Roberta Listro, Pasquale Linciano, Daniela Rossi et autres

The aberrant activation of the fibroblast growth factor 2 (FGF2)/fibroblast growth factor receptor (FGFR) signalling pathway drives severe pathologies, including cancer development and angiogenesis-driven pathologies. The perturbation of the FGF2/FGFR axis via extracellular allosteric small inhibitors is a promising strategy for developing …

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Figure S1 from ADAMDEC1 Maintains a Growth Factor Signaling Loop in Cancer Stem Cells

Ana Jimenez‐Pascual, James S. Hale, Anja Kordowski, Jamie Pugh et autres

Supplementary Figure S1

Figure S3 from ADAMDEC1 Maintains a Growth Factor Signaling Loop in Cancer Stem Cells

Ana Jimenez‐Pascual, James S. Hale, Anja Kordowski, Jamie Pugh et autres

Supplementary Figure S3

Data from ADAMDEC1 Maintains a Growth Factor Signaling Loop in Cancer Stem Cells

Ana Jimenez‐Pascual, James S. Hale, Anja Kordowski, Jamie Pugh et autres

Abstract Glioblastomas (GBM) are lethal brain tumors where poor outcome is attributed to cellular heterogeneity, therapeutic resistance, and a highly infiltrative nature. These characteristics are preferentially linked to GBM cancer stem cells (GSC), but how GSCs maintain their stemness is incompletely understood …

Figure S7 from ADAMDEC1 Maintains a Growth Factor Signaling Loop in Cancer Stem Cells

Ana Jimenez‐Pascual, James S. Hale, Anja Kordowski, Jamie Pugh et autres

Supplementary Figure S7

Figure S1 from ADAMDEC1 Maintains a Growth Factor Signaling Loop in Cancer Stem Cells

Ana Jimenez‐Pascual, James S. Hale, Anja Kordowski, Jamie Pugh et autres

Supplementary Figure S1