Tania Lobato

A Comprehensive Assessment of the Causal Relationship between Atopic Conditions and Pancreatic Cancer Risk: A Two-Sample Mendelian Randomization Study

Jiangchuan He, Sergio Sabroso-Lasa, Claudia Coscia, Evangelina López de Maturana et autres

BACKGROUND: Observational studies consistently report reduced pancreatic ductal adenocarcinoma (PDAC) risk among individuals with atopic conditions (asthma and rhinitis); however, the underlying biological mechanism remains unclear. This Mendelian randomization (MR) study investigated the potential causal relationship between atopy and PDAC by leveraging …

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Deciphering the role of complement system genes in pancreatic cancer susceptibility and prognosis

Alberto Langtry, Raúl Rabadán, Lola Alonso, Ioan Filip et autres

Pancreatic ductal adenocarcinoma (PDAC) genetic susceptibility is partially identified. The complement system (CS) influences carcinogenesis and participates in immunological defense and homeostasis; however, its role in PDAC genetic susceptibility and prognosis is underexplored. The association of SNPs within 111 CS-related genes with …

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Changes In Serum CXCL13 Levels Are Associated With Outcomes of Colorectal Cancer Patients Undergoing First-Line Oxaliplatin-Based Treatment

Sara Cabrero‐de las Heras, Xavier Hernández‐Yagüe, Andrea González, Ferrán Losa et autres

Metastatic colorectal cancer (mCRC) currently lacks reliable biomarkers for precision medicine, particularly for chemotherapy-based treatments. This study examines the behavior of 11 CXC chemokines in the blood of 104 mCRC patients undergoing first-line oxaliplatin-based treatment to pinpoint predictive and prognostic markers. Serum …

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Changes in serum CXCL13 levels are associated with outcomes of Colorectal Cancer Patients Undergoing First-Line Oxaliplatin-Based Treatment

Sara Cabrero‐de las Heras, Xavier Hernández‐Yagüe, Andrea González, Ferrán Losa et autres

Abstract Background Reliable biomarkers for precision medicine in metastatic colorectal cancer (mCRC) are needed. Blood biomarkers like chemokines may offer insights into overall tumor burden, yet, few prospective studies explore chemokine dynamics during treatment. This study investigates the behavior of a chemokine …

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Prognostic Impact of CD36 Immunohistochemical Expression in Patients with Muscle-Invasive Bladder Cancer Treated with Cystectomy and Adjuvant Chemotherapy

Juan Carlos Pardo, Tamara Sanhueza, Vicenç Ruiz de Porras, Olatz Etxániz et autres

Neoadjuvant chemotherapy followed by a cystectomy is the standard treatment in muscle-invasive bladder cancer (MIBC). However, the role of chemotherapy in the adjuvant setting remains controversial, and therefore new prognostic and predictive biomarkers are needed to improve the selection of MIBC patients. …

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759P Towards personalized medicine in MIBC: Immunohistochemistry-based taxonomical classification and outcome in patients treated with adjuvant chemotherapy

D. Castellano Gauna, Enrique Grande, Miguel Á. Climent Durán, Núria Laínez et autres

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Potential role of a clinical, taxonomical classification and RNA expression integrated signature to predict response to neoadjuvant platinum-based chemotherapy in muscle-invasive bladder cancer (MIBC) patients

Albert Font, Montserrat Domènech, José Luis Ramírez, J. Gago et autres

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The Polycomb group protein RING1B is overexpressed in ductal breast carcinoma and is required to sustain FAK steady state levels in breast cancer epithelial cells

Almudena Bosch, Konstantina Panoutsopoulou, Josep Corominas, Ramón Gimeno et autres

// Almudena Bosch 1,6 , Konstantina Panoutsopoulou 1 , Josep Maria Corominas 4 , Ramón Gimeno 5 , Gema Moreno-Bueno 2 , Juan Martín-Caballero 3 , Saleta Morales 2 , Tania Lobato 1 , Carles Martínez-Romero 1 , Eduardo F. Farias 6 …

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The epigenetic regulators Bmi1 and Ring1B are differentially regulated in pancreatitis and pancreatic ductal adenocarcinoma

Carles Martínez‐Romero, Ilse Rooman, Anouchka Skoudy, Carmen Guerra et autres

Chronic pancreatitis and pancreatic ductal adenocarcinoma (PDAC) are associated with major changes in cell differentiation. These changes may be at the basis of the increased risk for PDAC among patients with chronic pancreatitis. Polycomb proteins are epigenetic silencers expressed in adult stem …

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