Accès ouvert
2026
article
OpenAlex
YoungJun Yoo, Hamim Zahir, Shinichi Inaba, Kyoin Koo et autres
ABSTRACT Quizartinib is an oral, potent, selective FMS‐like tyrosine kinase 3 (FLT3) inhibitor, approved for the treatment of FLT3 ‐internal tandem duplication (ITD)–positive acute myeloid leukemia (AML) and under investigation in patients with newly diagnosed FLT3 ‐ITD–negative AML. Quizartinib is metabolized by …
us, jp
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Accès ouvert
2024
article
OpenAlex
Pavan K. Vaddady, Anaïs Glatard, Giovanni Smania, Shintaro Nakayama et autres
Abstract The population pharmacokinetics (PK) of quizartinib and its pharmacologically active metabolite AC886 have been previously described in healthy volunteers (HV) and relapsed/refractory (R/R) FLT3‐internal‐tandem‐duplication‐positive (FLT3‐IDT‐positive) acute myeloid leukemia (AML) patients receiving quizartinib monotherapy. In this analysis, we characterized the population PK …
us, jp
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Accès ouvert
2024
article
OpenAlex
Pavan K. Vaddady, Giovanni Smania, Shintaro Nakayama, Hiroyuki Inoue et autres
Abstract Quizartinib prolongs QT interval through inhibition of the slow delayed rectifier potassium current (IKs). We used non‐linear mixed‐effects modeling to explore the relationship between quizartinib and its pharmacologically active metabolite AC886 and the Fridericia‐corrected QT interval (QTcF) in newly diagnosed acute …
us, jp
(code pays fourni par la source)
2023
article
OpenAlex
Jiawen Liu, Ruoyun Tan, Min Geun Gu, Zijie Wang et autres
Aims: This study was designed to analyze the correlation between single nucleotide polymorphisms (SNP) related to drug metabolism and pharmacokinetics of mycophenolic acid (MPA) during long-term follow-up. Materials and Method: A retrospective cohort study involving 71 renal transplant recipients was designed. Blood …
cn
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Accès ouvert
2022
erratum
OpenAlex
Jiayi Zhang, Hengcheng Zhang, Zijie Wang, Haiwei Yang et autres
The correct Figure 3 and accompanying legend appears below. Figure 3 Expression of BTLA in rat allografts in the Allo + NC and Allo + BTLA groups. ( A ) IHC staining showed significantly upregulated BTLA expression in the kidney tissue of …
cn
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