Accès ouvert
2025
article
OpenAlex
Quenelle McKim, Lingshu Wang, Tongqing Zhou, Maryam Musayev et autres
Abstract Description SARS-CoV-2 neutralizing monoclonal antibodies (mAbs) serve as therapeutic agents to prevent or treat SARS-CoV-2 infection and have potential use against related coronaviruses (sarbecoviruses). However, evolving SARS-CoV-2 variants have rendered many mAbs ineffective. Therefore, we sought to identify potent mAbs with …
us
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Accès ouvert
2024
article
OpenAlex
Jianliang Xu, Tongqing Zhou, Krisha McKee, Baoshan Zhang et autres
Abstract Broadly neutralizing antibodies are proposed as therapeutic and prophylactic agents against HIV‐1, but their potency and breadth are less than optimal. This study describes the immunization of a llama with the prefusion‐stabilized HIV‐1 envelope (Env) trimer, BG505 DS‐SOSIP, and the identification …
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Accès ouvert
2023
article
OpenAlex
Hannah A. D. King, Vincent Dussupt, Letzibeth Mendez-Rivera, Bonnie M. Slike et autres
Introduction Antibody therapeutic strategies have served an important role during the COVID-19 pandemic, even as their effectiveness has waned with the emergence of escape variants. Here we sought to determine the concentration of convalescent immunoglobulin required to protect against disease from SARS-CoV-2 …
us
(code pays fourni par la source)