Sarah Acolatse

Figure S2 from Residual Breast Cancer Cells Co-opt SOX5-Driven Endochondral Ossification to Maintain Dormancy

Amulya Sreekumar, Eric R. Blankemeyer, Christopher J. Sterner, Tien-Chi Pan et autres

Supplementary Figure S2 shows Sox5 and Sox6 sgRNA editing efficiency, primary tumor and recurrent tumor growth rate at the orthotopic and metastatic site in MTB/TAN cells

Figure S5 from Residual Breast Cancer Cells Co-opt SOX5-Driven Endochondral Ossification to Maintain Dormancy

Amulya Sreekumar, Eric R. Blankemeyer, Christopher J. Sterner, Tien-Chi Pan et autres

Supplementary Figure S5 shows μCT and [18F]NaF PET in MTB/TAN cells as well as GFP positivity relative to Alcian blue staining

Supplementary Table S1 from Residual Breast Cancer Cells Co-opt SOX5-Driven Endochondral Ossification to Maintain Dormancy

Amulya Sreekumar, Eric R. Blankemeyer, Christopher J. Sterner, Tien-Chi Pan et autres

List of targets and sgRNAs used in the custom CRISPR-Cas9 screen. sgRNAs with validated editing efficiency are highlighted

Figure S1 from Residual Breast Cancer Cells Co-opt SOX5-Driven Endochondral Ossification to Maintain Dormancy

Amulya Sreekumar, Eric R. Blankemeyer, Christopher J. Sterner, Tien-Chi Pan et autres

Supplementary Figure S1 shows sgRNA distribution at each of the time points during disease progression as well as clonal enrichment for sgRNAs targeting Sox5 and Sox6 in MTB/TAN cells

Figure S4 from Residual Breast Cancer Cells Co-opt SOX5-Driven Endochondral Ossification to Maintain Dormancy

Amulya Sreekumar, Eric R. Blankemeyer, Christopher J. Sterner, Tien-Chi Pan et autres

Supplementary Figure S4 shows chondrogenesis and osteogenesis signature enrichment during dormancy in vitro in MTB/TAN cells as well as GFP positivity relative to Alcian blue staining

Figure S3 from Residual Breast Cancer Cells Co-opt SOX5-Driven Endochondral Ossification to Maintain Dormancy

Amulya Sreekumar, Eric R. Blankemeyer, Christopher J. Sterner, Tien-Chi Pan et autres

Supplementary Figure S3 shows Sox5 shRNA knockdown efficiency, proliferation and apoptosis rates in vitro and in vivo, and Sox5 sgRNA editing efficiency in nucleofected D2.OR cells

Data from Residual Breast Cancer Cells Co-opt SOX5-Driven Endochondral Ossification to Maintain Dormancy

Amulya Sreekumar, Eric R. Blankemeyer, Christopher J. Sterner, Tien-Chi Pan et autres

Abstract Recurrent breast cancer accounts for most disease-associated mortality and can develop decades after primary tumor therapy. Recurrences arise from residual tumor cells (RTC) that can evade therapy in a dormant state; however, the mechanisms enforcing dormancy in RTCs are poorly understood. …

Residual Breast Cancer Cells Co-opt SOX5-Driven Endochondral Ossification to Maintain Dormancy

Amulya Sreekumar, Eric R. Blankemeyer, Christopher J. Sterner, Tien-Chi Pan et autres

Recurrent breast cancer accounts for most disease-associated mortality and can develop decades after primary tumor therapy. Recurrences arise from residual tumor cells (RTC) that can evade therapy in a dormant state; however, the mechanisms enforcing dormancy in RTCs are poorly understood. CRISPR-Cas9 …

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Residual Breast Cancer Cells Co-opt SOX5-driven Endochondral Ossification to Maintain Dormancy

Amulya Sreekumar, Eric R. Blankemeyer, Christopher J. Sterner, Tien-Chi Pan et autres

Abstract Recurrent breast cancer accounts for most disease-associated mortality and can develop decades after primary tumor therapy. Recurrences arise from residual tumor cells (RTCs) that can evade therapy in a dormant state, however the mechanisms are poorly understood. CRISPR-Cas9 screening identified the …

us (code pays fourni par la source)

Host genetic background is a barrier to broadly effective vaccine–mediated protection against tuberculosis

Rocky Lai, Diana N. Gong, Travis Williams, Abiola F. Ogunsola et autres

Heterogeneity in human immune responses is difficult to model in standard laboratory mice. To understand how host variation affects Bacillus Calmette Guerin-induced (BCG-induced) immunity against Mycobacterium tuberculosis, we studied 24 unique collaborative cross (CC) mouse strains, which differ primarily in the genes …

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Host genetic background is a barrier to broadly effective vaccine protection: Relevance to BCG and Mycobacterium tuberculosis Infection

Rocky Lai, Diana N. Gong, Travis Williams, Abiola F. Ogunsola et autres

Summary The heterogeneity of immune responses observed in humans is difficult to model in standard inbred laboratory mice. To capture the diversity inherent in mice and better understand how host variation affects BCG-induced immunity against Mycobacterium tuberculosis , 24 unique Collaborative Cross …

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A heat-stable microparticle platform for oral micronutrient delivery

Aaron C. Anselmo, Xian Xu, Simone Buerkli, Yingying Zeng et autres

Micronutrient deficiencies affect up to 2 billion people and are the leading cause of cognitive and physical disorders in the developing world. Food fortification is effective in treating micronutrient deficiencies; however, its global implementation has been limited by technical challenges in maintaining …

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