Xiantao Song

Peripheral blood endothelial microparticles (CD144+) as a surrogate marker for coronary microcirculatory dysfunction in patients with stable coronary artery disease

Dao-Kuo Yao, Xiao-Song Ding, Bing Hua, Xiao-quan He et autres

Objectives In stable coronary artery disease (CAD), coronary microvascular dysfunction (CMD) is a prevalent cause of myocardial ischemia independent of epicardial stenoses. Although the index of microcirculatory resistance (IMR) is the invasive reference standard for CMD assessment, its routine use is limited …

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Optical Pumped Magnetometer Magnetocardiography in Left Main Disease With Coronary Microvascular Dysfunction

Shuwen Yang, Lanxin Feng, Ming Ding, Jianping Xiang et autres

BACKGROUND: Despite successful revascularization, a significant number of patients with obstructive coronary artery disease continue to experience angina because of often-overlooked coronary microvascular dysfunction (CMD). CASE SUMMARY: A 46-year-old man with hypertension, hyperlipidemia, and alcohol use presented with angina and left main …

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Virtual Stenting Based on Fractional Flow Reserve Derived from Computed Tomography in Predicting Post-Percutaneous Coronary Intervention Functional Outcomes: A Retrospective Cohort Study

Han Zhao, Yanlong Ren, Li Jiang, Mingduo Zhang et autres

With the advancement of fractional flow reserve (FFR) derived from computed tomography (FFRCT), virtual stenting technology has gradually developed. This study investigated the performance of virtual stenting based on FFRCT in predicting post-percutaneous coronary intervention (PCI) FFR. Data from 75 patients (78 …

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Triglyceride-glucose index as a novel biomarker for mild cognitive impairment in patients with coronary artery disease

Lanxin Feng, Jianan Li, Xin Zhao, Shuwen Yang et autres

BACKGROUND: Patients with coronary artery disease (CAD) are at an increased risk of cognitive impairment, yet reliable noninvasive biomarkers for identifying high-risk individuals in this population remain scarce. This study aimed to investigate the association between the triglyceride-glucose (TyG) index and cognitive …

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Predictive Accuracy of Magnetocardiography for Diagnosing Myocardial Ischemia in NSTE-ACS Patients With Residual Post-PCI Angina

Linqi Liu, Yilin Pan, Hai Gao, Yanyan Jin et autres

BACKGROUND: Post-percutaneous coronary intervention (PCI) angina affects 20% to 40% of non-ST-segment elevation acute coronary syndrome (NSTE-ACS) survivors but remains a clinical challenge due to its unpredictable course. OBJECTIVES: This study aimed to validate a rapid 90-second optically pumped magnetometer magnetocardiography (OPM-MCG) …

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Heart failure during adjuvant therapy for breast cancer: A case report

Huan Zhang, Zhao Ma, Shuwen Yang, Linqi Liu et autres

Abstract Background Breast cancer is one of the most common malignant tumors among women worldwide. Chemotherapeutic and targeted agents, as important adjuvant therapy for breast cancer, can also cause cardiotoxicity, leading to cardiac dysfunction. It is essential to recognize cardiotoxicity early, cease …

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Cardiac magnetic resonance follow-up of myocardial function in patients with chronic total occlusion of the coronary arteries: a retrospective cohort study

Jinfan Tian, Libo Liu, Xueyao Yang, Wenjing Xia et autres

Background: The impact of percutaneous coronary intervention (PCI) for chronic total occlusion (CTO) on myocardial function remains controversial. This study aims to evaluate changes in myocardial function following CTO-PCI using cardiac magnetic resonance (CMR) imaging and to identify the patient subgroups that …

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Bone marrow mesenchymal stem cell-derived extracellular vesicles alleviate diabetes-exacerbated atherosclerosis via AMPK/mTOR pathway-mediated autophagy-related macrophage polarization

Libo Liu, Ziyu An, Huan Zhang, Xueqi Wan et autres

INTRODUCTION: Bone marrow-derived mesenchymal stem cell-derived extracellular vesicles (BMSC-EVs) are widely used for therapeutic purposes in preclinical studies. However, their utility in treating diabetes-associated atherosclerosis remains largely unexplored. Here, we aimed to characterize BMSC-EV-mediated regulation of autophagy and macrophage polarization. METHODS: mouse …

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The cGAS-STING/PERK-eIF2α: Individual or Potentially Collaborative Signaling Transduction in Cardiovascular Diseases

Xueqi Wan, Huan Zhang, Jinfan Tian, Libo Liu et autres

Over the past several decades, a canonical pathway called the cyclic GMP-AMP (cGAMP) synthase (cGAS)-stimulator of interferon genes (STING) mediating type I interferon (IFN) release via TANK-binding kinase 1(TBK1) / IFN regulatory factor 3 (IRF3) pathway has been widely investigated and characterized. …

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Diagnostic Value of Magnetocardiography to Detect Abnormal Myocardial Perfusion: A Pilot Study

Huan Zhang, Zhao Ma, Hongzhi Mi, Jian Jiao et autres

Background: Magnetocardiography (MCG) is a novel non-invasive technique that detects subtle magnetic fields generated by cardiomyocyte electrical activity, offering sensitive detection of myocardial ischemia. This study aimed to assess the ability of MCG to predict impaired myocardial perfusion using single-photon emission computed …

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Association of BMI, lipid-lowering medication, and age with prevalence of type 2 diabetes in adults with heterozygous familial hypercholesterolaemia: a worldwide cross-sectional study

Amany K. Elshorbagy, Alexander R.M. Lyons, Antonio J. Vallejo‐Vaz, Christophe A. T. Stevens et autres

BACKGROUND: Statins are the cornerstone treatment for patients with heterozygous familial hypercholesterolaemia but research suggests it could increase the risk of type 2 diabetes in the general population. A low prevalence of type 2 diabetes was reported in some familial hypercholesterolaemia cohorts, …

Performance of artificial intelligence in detecting the chronic total occlusive lesions of coronary artery based on coronary computed tomographic angiography

Yanying Yang, Zhen Xian Zhou, Nan Zhang, Rui Wang et autres

Background: Coronary chronic total occlusion (CTO) increases the risk of developing major adverse cardiovascular events (MACE) and cardiogenic shock. Coronary computed tomography angiography (CCTA) is a safe, noninvasive method to diagnose CTO lesions. With the development of artificial intelligence (AI), AI has …

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